Normal locomotion in zebrafish lacking the sodium channel NaV1.4 suggests that the need for muscle action potentials is not universal

It is widely accepted that action potentials in vertebrate muscle are indispensable for contraction. This study of zebrafish lacking the sodium channel NaV1.4 reveals that NaVs are not essential for muscle contraction, and that the physiological requirement for action potentials in muscle can vary between vertebrates.