Will Klotho Prevent or Slow Dementia?
Klotho: Hope For Increased Longevity And Reduced Neurodegenerative Disease
“Renewed interest in a protein called klotho is pervading the scientific world. Klotho is a known anti-inflammatory protein that also contains anti-aging properties. In this two-part series, we will explore what klotho is, how it might impact inflammatory brain diseases, and how it ultimately prevents aging.”
#alzheimers #dementia #longevity #klotho #lecanemab #donanemab #aging
https://www.forbes.com/sites/williamhaseltine/2023/02/20/klotho-hope-for-increased-longevity-and-reduced-neurodegenerative-disease-part-1/
Klotho: Hope For Increased Longevity And Reduced Neurodegenerative Disease (Part 1)
In this short series, I provide a brief overview of an anti-aging protein called klotho and how it may lead to new insights and treatments for age-related diseases.
A breakthrough in #Alzheimers disease
The promising potential of #Klotho
“I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our body, that helps with #Longevity, that helps with other organ systems and enhances the brain.” —#DenaDubal
https://cnmri.com/2024/05/29/a-breakthrough-in-alzheimers-disease/
A breakthrough in Alzheimer’s disease
A breakthrough in Alzheimer’s disease The promising potential of klotho “I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our bod…
Turning the tap on the Fountain of Youth? Restoring youth to old brains with PF4
Longevity factor #klotho enhances #cognition in aged non-human primates
"...Collectively, our data show that KL enhanced cognition in aging rhesus macaques..."
Animal model, but potentially interesting results
#Aging #Science #Research #Dementia
https://www.nature.com/articles/s43587-023-00441-x
Longevity factor klotho enhances cognition in aged nonhuman primates | Nature Aging
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans. Cognitive dysfunction in aging is a major biomedical challenge without medical therapies. Here, Castner et al. show that longevity factor klotho enhances cognition in aged nonhuman primates, increasing its relevance for a therapeutic path to humans.
Oh, mysterious klotho, your power I can see
Your injection brings benefits to me
Your gift of a brain boost
Gives us a chance to take the absolute most
From the memory that you so graciously bestow
#klotho #brainboost #memory #science #ode #poetry
https://www.wired.com/story/one-shot-of-a-kidney-protein-gave-monkeys-a-brain-boost/
One Shot of a Kidney Protein Gave Monkeys a Brain Boost
An early experiment in older rhesus macaques suggests that an injection of klotho improves working memory. Could it one day help people?
Dosis baja de proteína #Klotho (obtenida de mono rhesus) parece mejorar la cognición en ratones 🤔😑
https://www.nature.com/articles/s43587-023-00441-x
Longevity factor klotho enhances cognition in aged nonhuman primates | Nature Aging
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans. Cognitive dysfunction in aging is a major biomedical challenge without medical therapies. Here, Castner et al. show that longevity factor klotho enhances cognition in aged nonhuman primates, increasing its relevance for a therapeutic path to humans.
Protein „verjüngt“ alterndes Gedächtnis. Einmalige Gabe des Klotho-Proteins verbessert geistige Leistungen von alten Rhesusaffen.
#Klotho #Gedaechtnis #Alter #geistigeFitness #Gehirn #Medizinhttps://www.scinexx.de/news/medizin/protein-verjuengt-alterndes-gedaechtnis/
Protein "verjüngt" alterndes Gedächtnis
Gegen den geistigen Abbau: Ein Proteinhormon namens "Klotho" könnte dem geistigen Abbau im Alter entgegenwirken, wie ein Test mit Rhesusaffen nahelegt.
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