Leibniz-HKIJun 17, 2025

How does the gut stay healthy during worm infections? 🛡️🪱 A new Canadian-German study in #Cell shows #interferons help protect tissue. Not by killing worms, but by boosting gut resilience!

🗞️ News article: https://lmy.de/qMldA
💡Publication: https://lmy.de/wcghm

#DiseaseTolerance #InfectionBiology #LeibnizHKI

The EMBO JournalNov 6, 2023

MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to #autoimmunity

Pathology of primary Sjögren's syndrome is known to involve #interferons, but Enrique Martin-Gayo et al @UAM_Medicina show additional roles also for #innateimmune cells like natural killer and #dendritic cells

https://www.embopress.org/doi/full/10.15252/embj.2023113714

beSpacificOct 17, 2023
Full text study from Cell - https://www.cell.com/cell/fulltext/S0092-8674(23)01034-6
>#LongCOVID is associated with reduced circulating #serotonin levels
>Serotonin depletion is driven by viral #RNA-induced type I #interferons (IFNs)
>IFNs reduce serotonin through diminished# tryptophan uptake and #hypercoagulability
>Peripheral serotonin deficiency impairs #cognition via reduced #vagal signaling
Giuseppe MichieliJun 13, 2023
Jacob RA, Zhang A, Ajoge HO, D’Agostino MR, Nirmalarajah K, Shigayeva A, et al. Sensitivity to neutralizing #antibodies and #resistance to type I #interferons in #SARS-CoV-2 #R1 lineage #variants, #Canada. Emerg Infect Dis. 2023 Jul [date cited]. https://doi.org/10.3201/eid2907.230198
halama_immunoApr 11, 2023
When the immune system attacks the immune system: #Autoantibodies against #interferons (type I) have an impact on #immuneresponses and are associated with viral disease susceptibility as outlined in this elegant review... #immunology #virology #cytokines #infections #autoimmunity #immunoregulation
https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250164
Show threadhalama_immunoJan 23, 2023
@chfloudas It also brings up the question, what type of #ImmuneResponse delivers the best impact against the tumor bulk...suggestive of non-canonical responses beyond #interferons or synergistic #innateimmunity activation #immunology