Foundations for type 1 diabetes may already be laid during pregnancy

The researchers emphasize that the study is not intended to predict disease in individuals

Scientists identify target to treat devastating brain disease

This discovery opens the door to the first targeted drug therapies for anti-NMDA receptor encephalitis

#Autoantibodies in #longCOVID: a systematic #review

Humoral determinants of checkpoint immunotherapy - Nature

Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

Prevalence of #EBV, #HHV6, #HCMV, #HAdV, #SARS-CoV-2, and #Autoantibodies to Type I #Interferon in #Sputum from Myalgic Encephalomyelitis / #CFS Patients

Prevalent and persistent new-onset #autoantibodies in mild to severe #COVID19

Source: Nature Communications, AbstractAutoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset au…

BugBitten How an anti-hero of the immune system protects from malaria

Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system

Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune response and cytokine storm. Autoantibodies in COVID-19 may have severe prodromal effects that are poorly understood. The interaction between these autoantibodies and self-antigens can result in systemic inflammation and organ dysfunction. However, the role of autoantibodies in COVID-19 complications has yet to be fully understood.Methods: The current investigation screened two independent cohorts of 97 COVID-19 patients [discovery (Disc) cohort from Qatar (case = 49 vs. control = 48) and replication (Rep) cohort from New York (case = 48 vs. control = 28)] utilizing high-throughput KoRectly Expressed (KREX) Immunome protein-array technology. Total IgG autoantibody responses were evaluated against 1,318 correctly folded and full-length human proteins. Samples were randomly applied on the precoated microarray slides for 2 h. Cy3-labeled secondary antibodies were used to detect IgG autoantibody response. Slides were scanned at a fixed gain setting using the Agilent fluorescence microarray scanner, generating a 16-bit TIFF file. Group comparisons were performed using a linear model and Fisher’s exact test. Differentially expressed proteins were used for KEGG and WIKIpathway annotation to determine pathways in which the proteins of interest were significantly over-represented.Results and conclusion: Autoantibody responses to 57 proteins were significantly altered in the ...