Migraine is more than a headache – a rethink offers hope | Hacker News

Link📌 Summary: 本文探討了偏頭痛的最新研究進展及新型藥物的潛力。特別是 gepants 類藥物的出現,讓許多患者,包括 Andrea West,在持續多年的偏頭痛中找到了解決方案。文中提到,過去對偏頭痛的理解主要以血管和心理問題為主,現在的研究強調偏頭痛的生物學機制,展示出更全面的病因。此外,科學家們正尋找偏頭痛發作的觸發因素,從基本的神經系統到環境因素都可能影響病情。

🎯 Key Points:
- Gepants 是新一代偏頭痛藥物,已在英國獲準使用。
- 偏頭痛的症狀多樣,且並不僅限於痛苦的頭痛,而是包括腦霧、感光和疲勞等。
- 新研究顯示,偏頭痛的產生與大腦活動的改變及特定生物標記有關。
- 需要更全面的研究來瞭解偏頭痛的觸發機制,以制定有效治療策略。
- 預防和管理偏頭痛的藥物,如 CGRP 抑制劑,對某些患者效果顯著,但仍然存在適應性與普及性的挑戰。

🔖 Keywords: #偏頭痛 #Gepants #CGRP #生物學機制 #新藥研究

Migraine is more than a headache – a rethink offers hope | Hacker News

The American Headache Society is just out with a position statement recommending the use of anti-CGRP (anti-Calcitonin Gene-Related Peptide drugs) as drug therapy for the prevention of migraines. #migraines #CGRP #antibodies #gepants #prevention #headaches
https://www.instagram.com/p/DBuF7AgNVJX/
Howard G. Smith MD, AM on Instagram: "A New Drug Strategy For Preventing Migraine Headaches The American Headache Society is just out with a position statement recommending the use of anti-CGRP drug therapy for the prevention of migraines. Calcitonin Gene-Related Peptides, CGRPs for short, have been recognized as drivers of these devastating headaches. A meta-analysis of the studies that tested the drugs that block them have proven their effectiveness. These drugs include the antibodies erenumab, marketed as Aimovig, galcanezumab, branded as Emgality, fremanezumab, marketed as Ajovy, and epitinezumab, branded Vyepti. Also extremely effective are the gepant drugs atogepant, marketed Qulipta, zavegepant, branded Zavzpret, rimegepant, marketed as Nurtec, and ubrogepant, marketed as Ubrelvy. Neurologists specializing in the management of headaches have embraced the use of these drugs. They now recommend their use to primary care physicians who manage 75% of patients with migraine headaches. If you are a migraine sufferer, do ask your medical team about these medications. https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14692 https://www.medscape.com/viewarticle/new-first-line-therapies-migraine-2024a1000edv #migraines #CGRP #antibodies #gepants #prevention #headaches"

0 likes, 0 comments - drhowardsmithreports on October 29, 2024: "A New Drug Strategy For Preventing Migraine Headaches The American Headache Society is just out with a position statement recommending the use of anti-CGRP drug therapy for the prevention of migraines. Calcitonin Gene-Related Peptides, CGRPs for short, have been recognized as drivers of these devastating headaches. A meta-analysis of the studies that tested the drugs that block them have proven their effectiveness. These drugs include the antibodies erenumab, marketed as Aimovig, galcanezumab, branded as Emgality, fremanezumab, marketed as Ajovy, and epitinezumab, branded Vyepti. Also extremely effective are the gepant drugs atogepant, marketed Qulipta, zavegepant, branded Zavzpret, rimegepant, marketed as Nurtec, and ubrogepant, marketed as Ubrelvy. Neurologists specializing in the management of headaches have embraced the use of these drugs. They now recommend their use to primary care physicians who manage 75% of patients with migraine headaches. If you are a migraine sufferer, do ask your medical team about these medications. https://headachejournal.onlinelibrary.wiley.com/doi/10.1111/head.14692 https://www.medscape.com/viewarticle/new-first-line-therapies-migraine-2024a1000edv #migraines #CGRP #antibodies #gepants #prevention #headaches".

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Today we learnt that there's an overlap between neurodivergence (especially autism) and migraines.

We've had several instances recently, particularly where we've pushed ourselves too far, where we've experienced what we thought were neurodivergent verbal shutdowns, as we're AuDHD.

We'd experienced such things for at least a couple of decades, even before our ASD diagnosis (still waiting on the ADHD one though). We previously attributed it to normal fatigue. Then we'd describe it as a language centre collapse (or a full batting collapse).

However, it was never clear why painkillers like ibuprofen lysine or naproxen (NSAIDs), paracetamol, or codeine phosphate always helped to both prevent or alleviate symptoms.

Warning signs for us have typically been:

  • Increasing pain in middle of forehead or above eyes
  • Increased light sensitivity.
    • We've often had to wear our prescription sunglasses to keep working.
  • Feeling more fatigued and finding it difficult to focus.
  • Finding it harder to understand spoken or written language.
  • Slurred speech and difficulty writing.
  • Making silly errors and typos.

Once it gets fully going, symptoms include:

  • Aphasia.
  • Trouble with body coordination.
  • Partial or total verbal shutdown.
    • One time Evie couldn't even think coherent sentences, so our headmate Hannah told us what to write to communicate with our wife.

All this time, we'd been thinking this was solely a neurodivergent overload issue. But now we've found out it might actually be some form of migraine, sand this is potentially something we can get meds for (such as gepants).

We intend to book an appointment with our GP about it to investigate further, as it's happening increasingly often, especially since we entered AuDHD burnout.

For further context, headaches are common in our family and our sister has migraines with auras.

#neurodivergent #neurodivergence #ActuallyAutistic #ADHD #AuDHD #VerbalShutdown #migraine #AuDHDBurnout #NeurodivergentBurnout #gepants #NSAID #codeine

“Going non verbal” isn’t a thing

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