Một dự án mới sử dụng AI kết hợp đồ tri thức để tái định vị công dụng của thuốc. Công cụ này giúp nhà nghiên cứu tìm ra thuốc cũ có thể trị bệnh mới, đồng thời hiển thị các bước luận giải một cách minh bạch. Dự án vẫn ở giai đoạn thử nghiệm.
#AI #DrugRepurposing #SideProject #HealthTech #Research #YKhoa #DuAnPhu #CongNgheSucKhoe #NghienCuu
🚀 Dự án phụ: công cụ khám phá tái sử dụng thuốc dựa trên AI giải thích được. Kết hợp knowledge graph và XAI để xếp hạng cặp thuốc‑bệnh, hiển thị đường dẫn lý luận (thuốc → mục tiêu → đường truyền → bệnh). Xây dựng bằng Python + React, hiện dùng dữ liệu mô phỏng. Mong nhận phản hồi về tính hữu ích, dữ liệu thực và cải tiến. #AI #DrugRepurposing #Research #SideProject #CôngNghệ #YHọc
Blood pressure drug, meet brain cancer. Scientists just uncovered how hydralazine “silences” glioblastoma cells, a 70-year-old medical mystery solved, and a ray of hope for patients. Is drug repurposing the future? Explore more at The Urban Herald!
https://theurb.co/hydralazine-brain-tumor-drug
#BrainCancer #Glioblastoma #CancerBreakthrough #MedicalInnovation #DrugRepurposing #CancerResearch #HealthNews #NeuroOncology #Hydralazine #ScienceExplained #News
Discover how hydralazine, a 70-year-old blood pressure drug, may revolutionise glioblastoma treatment by targeting the ADO enzyme. Learn about this breakthrough in brain tumour research, the science of cellular senescence, and future clinical implications for aggressive brain cancer therapy.
Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
https://youtu.be/od0epKW19og
[13:03] hydroxyurea used to treat a person with POTS and MCAS
Here's an article on the topic:
Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9388361/
"First used 60 years ago for chronic myeloproliferative neoplasms, HU is now standard of care in reducing the severity of sickle cell disease (SCD) (McGann and Ware 2015). In this context, it is of interest that in animal models and human subjects with SCD, medications that reduce MC activation decreased bone pain (Vincent et al. 2013, 2016). HU also inhibits replication of human immunodeficiency virus-1 (HIV-1) and has been used in therapy of cyanotic congenital heart disease (Lori and Lisziewicz 2000; Reiss et al. 2007). A theoretic explanation for effectiveness of HU in these diseases include reducing MC activity independent of anti-proliferative effects. HU could decrease activity and ability of GI mucosal MCs that capture HIV-1 and mediate trans-infection of CD4 + T cells (Jiang et al. 2015). Similarly, HU could reduce the activity of the increased numbers of chymase-containing MCs in lung tissue of congenital heart disease patients and, thereby, decrease severity of these pulmonary and cardiac diseases (Hamada et al. 1999)."
The mechanisms are probably quite complex. One facet is that hydroxyurea increases fetal hemoglobin production and RBC membrane flexibility - which could increase O2 perfusion. Hypoxia activates mast cells.
#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology
💊 New in #DrugRepurposing Journal (Vol. 2, Issue 1):
"Role of Chemoinformatics & Machine Learning in Drug Repurposing"
From virtual screening & molecular docking to AI & AlphaFold — computational tools are transforming how we find new uses for old drugs.
📖 💊 New Issue Alert!
Drug Repurposing Vol 2, Issue 1 is out! 5 exciting articles explore AI, chemoinformatics, VR collaboration, and more — showing how existing drugs can find new therapeutic uses.
Genomica avanzata, terapie innovative ed intelligenza artificiale. La genetica italiana tra presente e futuro. Si terrà al Palacongressi di Rimini dal 23 al 25 settembre il XXVIII Congresso Nazionale della Società Italiana di Genetica Umana (SIGU) Come la genetica sta cambiando e sempre più cambierà la prevenzione e la cura delle malattie? Quali nuove frontiere stanno aprendo...
#CongressoNazionale #drugrepurposing #geneticaumana #Genomicaavanzata #oncogenetica #SIGU
A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229
lots of details on #pathophysiology in this review
#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
#WASF3
'RePo-SUDOE: A Transnational Network for Drug Repurposing in the SUDOE Space' - a new #DrugRepurposing article 💎 open access on #ScienceOpen 🔓📰
➡️ https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/DRUGREPO.25.1.0004
#REPO4EU #RePoSUDOE #CancerResearch #SUDOE #TherapeuticTargets
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d13493990e380">The development of new drugs is hindered by high failure rates, substantial costs, and prolonged timelines, highlighting the importance of drug repurposing (or drug repositioning) as a key strategy to identify new therapeutic applications for existing drugs. Despite its potential, collaboration within the SUDOE space, concerning Portugal, Spain, and France, remains limited, as evidenced by a bibliometric analysis that reveals their relatively modest contribution to global drug repurposing research in comparison to leading countries, such as China, USA, and UK. The RePo-SUDOE project aims to address this gap by bringing together diverse partners to advance drug repurposing technologies and enhance the region’s competitiveness in this field. The project includes three key objectives: (i) raising awareness and understanding of drug repurposing technologies, positioning SUDOE’s R&D centers as leaders in European research; (ii) fostering multidisciplinary collaboration and identifying opportunities for innovative drug repurposing initiatives across the SUDOE space through the establishment of a transnational network with a key focus of developing methodologies for drug repurposing for cancer treatment; (iii) creating a prototype of a three-dimensional visualization room for biological systems with virtual and augmented reality technologies to explore drug–target interactions, engaging STEAM students and researchers in immersive learning. The RePo-SUDOE project brings together diverse partners from the SUDOE space to collaborate on drug repurposing, making scientific information more accessible, and using advanced visualization technologies to strengthen the field in this geographic region. </p>
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