Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance [2020]
abstract:
https://pubmed.ncbi.nlm.nih.gov/32777256/
preprint can be downloaded here:
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463265
#orosomucoid #fatigue #erythromycin #DrugRepurposing #DrugDevelopment
At present, there are still no official or semi-official recommendations for the treatment of muscle fatigue. We previously reported that acute phase protein orosomucoid (ORM) can enhance muscle endurance and exert anti-fatigue effect. In attempting to seek anti-fatigue drugs that target ORM, we fou …
Một dự án mới sử dụng AI kết hợp đồ tri thức để tái định vị công dụng của thuốc. Công cụ này giúp nhà nghiên cứu tìm ra thuốc cũ có thể trị bệnh mới, đồng thời hiển thị các bước luận giải một cách minh bạch. Dự án vẫn ở giai đoạn thử nghiệm.
#AI #DrugRepurposing #SideProject #HealthTech #Research #YKhoa #DuAnPhu #CongNgheSucKhoe #NghienCuu
🚀 Dự án phụ: công cụ khám phá tái sử dụng thuốc dựa trên AI giải thích được. Kết hợp knowledge graph và XAI để xếp hạng cặp thuốc‑bệnh, hiển thị đường dẫn lý luận (thuốc → mục tiêu → đường truyền → bệnh). Xây dựng bằng Python + React, hiện dùng dữ liệu mô phỏng. Mong nhận phản hồi về tính hữu ích, dữ liệu thực và cải tiến. #AI #DrugRepurposing #Research #SideProject #CôngNghệ #YHọc
Blood pressure drug, meet brain cancer. Scientists just uncovered how hydralazine “silences” glioblastoma cells, a 70-year-old medical mystery solved, and a ray of hope for patients. Is drug repurposing the future? Explore more at The Urban Herald!
https://theurb.co/hydralazine-brain-tumor-drug
#BrainCancer #Glioblastoma #CancerBreakthrough #MedicalInnovation #DrugRepurposing #CancerResearch #HealthNews #NeuroOncology #Hydralazine #ScienceExplained #News
Discover how hydralazine, a 70-year-old blood pressure drug, may revolutionise glioblastoma treatment by targeting the ADO enzyme. Learn about this breakthrough in brain tumour research, the science of cellular senescence, and future clinical implications for aggressive brain cancer therapy.
Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
https://youtu.be/od0epKW19og
[13:03] hydroxyurea used to treat a person with POTS and MCAS
Here's an article on the topic:
Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9388361/
"First used 60 years ago for chronic myeloproliferative neoplasms, HU is now standard of care in reducing the severity of sickle cell disease (SCD) (McGann and Ware 2015). In this context, it is of interest that in animal models and human subjects with SCD, medications that reduce MC activation decreased bone pain (Vincent et al. 2013, 2016). HU also inhibits replication of human immunodeficiency virus-1 (HIV-1) and has been used in therapy of cyanotic congenital heart disease (Lori and Lisziewicz 2000; Reiss et al. 2007). A theoretic explanation for effectiveness of HU in these diseases include reducing MC activity independent of anti-proliferative effects. HU could decrease activity and ability of GI mucosal MCs that capture HIV-1 and mediate trans-infection of CD4 + T cells (Jiang et al. 2015). Similarly, HU could reduce the activity of the increased numbers of chymase-containing MCs in lung tissue of congenital heart disease patients and, thereby, decrease severity of these pulmonary and cardiac diseases (Hamada et al. 1999)."
The mechanisms are probably quite complex. One facet is that hydroxyurea increases fetal hemoglobin production and RBC membrane flexibility - which could increase O2 perfusion. Hypoxia activates mast cells.
#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology
💊 New in #DrugRepurposing Journal (Vol. 2, Issue 1):
"Role of Chemoinformatics & Machine Learning in Drug Repurposing"
From virtual screening & molecular docking to AI & AlphaFold — computational tools are transforming how we find new uses for old drugs.
📖 💊 New Issue Alert!
Drug Repurposing Vol 2, Issue 1 is out! 5 exciting articles explore AI, chemoinformatics, VR collaboration, and more — showing how existing drugs can find new therapeutic uses.
Genomica avanzata, terapie innovative ed intelligenza artificiale. La genetica italiana tra presente e futuro. Si terrà al Palacongressi di Rimini dal 23 al 25 settembre il XXVIII Congresso Nazionale della Società Italiana di Genetica Umana (SIGU) Come la genetica sta cambiando e sempre più cambierà la prevenzione e la cura delle malattie? Quali nuove frontiere stanno aprendo...
#CongressoNazionale #drugrepurposing #geneticaumana #Genomicaavanzata #oncogenetica #SIGU
A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229
lots of details on #pathophysiology in this review
#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
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