A non-antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti-fatigue protein orosomucoid in mice [2024]
At present, there are no official approved drugs for improving muscle endurance. Our previous research found acute phase protein orosomucoid (ORM) is an endogenous anti-fatigue protein, and macrolides antibiotics erythromycin can elevate ORM level to increase muscle bioenergetics and endurance param …
Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance [2020]
abstract:
https://pubmed.ncbi.nlm.nih.gov/32777256/
preprint can be downloaded here:
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463265
#orosomucoid #fatigue #erythromycin #DrugRepurposing #DrugDevelopment
At present, there are still no official or semi-official recommendations for the treatment of muscle fatigue. We previously reported that acute phase protein orosomucoid (ORM) can enhance muscle endurance and exert anti-fatigue effect. In attempting to seek anti-fatigue drugs that target ORM, we fou …
Antibiotics Those Inhibit Nucleic Acid And Protein Synthesis
#Bacteria, #Chloramphenicol, #Erythromycin, #Streptomycin, #Tetracyclines #Microbiology Synthesis of nucleic acid and protein involves a series of complex biochemical reactions. The mode of action of such antibiotics…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
A recent review of the evidence on #erythromycin for #gastroparesis from the NHS’ Specialist Pharmacy Service: https://www.sps.nhs.uk/articles/what-is-the-optimal-prokinetic-dose-of-erythromycin-in-adults-2/
TL;DR: “Long term oral use is limited by poor tolerance, modest efficacy and the development of tachyphylaxis (rapidly diminishing response to drug therapy).”
My GP prescribed it to me so I’ll give it a shot, but I won’t stay on it. It also interacts with diazepam, to which I’m very sensitive because of physical dependence.
Rhyothemis
micrordt
Cyrus