Interesting ChemRxiv preprint by the group of Tom Wennekes with first author Jun Yang Ong. They show that chlorotriazine (ClTriZ) reactive groups are compatible with dual click direct-to-biology (D2B) approaches and can yield potent and selective protein labeling tools.

https://chemrxiv.org/doi/full/10.26434/chemrxiv-2025-4kzhd
#Chemistry #ChemBio #Glycotime #D2B

Amazing talk by Jana Volaric from our Molecular Physiology Department and @LED3hub at #KNCVMCCB2026. She talked about her postdoctoral research in the Ed Tate lab into optical control of S-acyltransferase activity in mammalian cells.

#Chemistry #ChemBio #GeneticCodeExpansion

Laura Wijffelaars gave an interesting talk at #KNCVMCCB2026. She talked about her research into an ACKR3 inverse agonist with potential in the treatment of #MultipleSclerosis.

#Chemistry #ChemBio #DrugDiscovery #MS

Interesting talk by Karlijn Meerman at #KNCVMCCB2026. She talked about her #PhD research in the group of Ben Feringa about making photoswitchable cyclic peptides in collaboration with Nathaniel Martin of our @LED3hub.

#Chemistry #ChemBio #Peptides #PhotoSwitch

How can virtual screening be combined with in-house synthesis to quickly evaluate hits?

Sean McKenna from our @LED3hub talked about his exciting work on COMBINAUT that allows automated synthesis and purification.

https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000200/v1
#Chemistry #ChemBio #DrugDiscovery

Interesting talk by Emira Visser at #KNCVMCCB2026. She talked about her #PhD research in the group of Luc Brunsveld on the development of molecular glues for the interaction between Carbohydrate Response Element Binding Protein (ChREBP) and 14-3-3.

https://www.nature.com/articles/s41467-025-57241-7
#Chemistry #ChemBio