Predicting the stereochemical outcome of glycosylation reactions is a complex problem.
In his talk at #Lunteren2026, Daan Hoogers from the group of Jeroen Codee of our @LED3hub presented his research into the systematic exploration of this question with various methods.
https://pubs.rsc.org/en/content/articlelanding/2026/sc/d5sc07201h
#Chemistry #ChemBio #Glycotime
Great to hear the full story of this exciting project that is done in collaboration with, among others, Madeline Kavanagh, of our @LED3hub. (2/2)
#ChemBio #Chemistry #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL
We urgently need new antibiotics against the most devastating Gram-negative infections. Nevertheless, bringing new classes of antibiotics against them to the clinics has been a huge challenge.
I am very happy that Thomas Clairfeuille from Roche will visit us for a @LED3hub Lecture on March 26th to talk about one of the recent success stories in the field: Zosurabalpin, which targets the LPS transport. (1/2)
We are looking forward to the LED3 Lecture by Thomas Clairfeuille from the Roche Innovation Center on March 26th. He will talk about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".
If you are interested, make sure to come by!
https://www.universiteitleiden.nl/en/science/led3/led3-lectures
RE: https://mstdn.science/@LED3hub/116160224869791384
It was great to be part of the discussion about the faculty priority themes of our Faculty of Science and to represent the @LED3hub alongside Mario van der Stelt, Laura Heitman and Kim Bonger.
Our theme leader, Mario van der Stelt, introduces our LED3 hub at the meeting of all of our faculty priority themes of our Science Faculty. Great discussions on the annual and communication plan as well as the outlook for the future. Many exciting things are ahead.
Interested in Activity-based Protein Profiling?
We are excited to host the 15th Activity-based Protein Profiling meeting (@ABPP2027 #ABPP2027) on June 2nd to 4th, 2027, at Naturalis in Leiden.
Save the date and sign up for our mailing list: https://www.universiteitleiden.nl/en/science/led3/abpp2027
Amazing @LED3hub Lecture by Christina Woo! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation.
https://www.nature.com/articles/s41586-022-05333-5
Great insights into function and biosynthesis of cyclic imids with important implications for therapeutic degraders.
https://www.nature.com/articles/s41589-025-02106-9
She also talked about the identification of an allosteric binding site on cereblon to modulate the potency of degraders. https://www.nature.com/articles/s41586-025-09994-w
Stephan Hacker
