A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00229
lots of details on #pathophysiology in this review
#MECFS #LongCovid #metformin #DrugRepurposing #medicine #health
#WASF3
From the NIH:
"Protein [WASF3] may be linked to exercise intolerance in ME/CFS"
"A study suggested that high levels of a protein may reduce energy production in the muscle cells of people with ME/CFS."
"Blocking this protein in cells in the lab restored energy production, suggesting a potential new strategy for treating the condition."
Auch die Pharmazeutische Zeitung hat die #WASF3-Studie zu #MECFS aufgegriffen und wesentliche Aspekte auf Deutsch zusammengefasst.
https://www.pharmazeutische-zeitung.de/steckt-dieses-protein-dahinter-141814/
Since the article about #WASF3 in #MECFS is behind a paywall here is another link to the topic. This text is also a bit more layman friendly.
"Endoplamic reticulum stress–induced #WASF3 protein localizes to #mitochondria and disrupts respiratory supercomplex assembly, leading to decreased oxygen consumption and exercise endurance. Alleviating ER stress decreases WASF3 and restores mitochondrial function, indicating that WASF3 can impair skeletal muscle #bioenergetics and may be targetable for treating #fatigue symptoms."
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ahimsa
Corrosive Dream