Newly discovered nerve cells perceive more than just edges

The visual cortex is the part of the brain that enables visual perception. Millions of nerve cells process stimuli from the outside world - only reacting to objects with certain characteristics. According to textbooks, the first stage of the visual cortex has two main types of neurons that specialize in edges – sharp transitions between light and dark. An international team of researchers used machine learning techniques to find neurons in mice that use a previously unknown process in the brain to share this cognitive processing: https://www.uni-goettingen.de/en/3240.html?id=8101

Research in #NatureNeuroscience: https://doi.org/10.1038/s41593-026-02213-3

Now out in #NatureNeuroscience: "Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice".

Congrats to first authors Ann Bright, Yana Kotlyarenko, Florian Neuhaus — and thanks to all collaborators!

https://www.nature.com/articles/s41593-025-01999-y

#NewsMayerlab #NeuroFediverse #SingleCell #DevelopmentalBiology

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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor maturation is gated by developmental timing, revealing a distinct regulatory logic underlying the development of inhibitory neurons.

Nature

Hearing begins with the stretching of elastic molecular “springs” that open ion channels in the sensory hair cells of the ear. For decades, researchers have been unable to find these.

Now, a team at Göttingen's Excellence Cluster Multiscale Bioimaging #MBExC has discovered just such a spring for the first time: https://www.uni-goettingen.de/en/3240.html?id=7736

#NatureNeuroscience: https://doi.org/n86s #MakingSenseOfSenses #Hearing

Information for the Media - Georg-August-University Göttingen

Website of the Georg-August-University Göttingen

Georg-August Universität Göttingen

Heute, am 3. März, ist Welttag des Hörens! Doch wie funktioniert eigentlich das #Gehör?

Ein Team des Göttinger Exzellenzclusters „Multiscale Bioimaging“ (#MBExC), an dem auch unsere Uni beteiligt ist, hat dazu eine zentrale Struktur entdeckt. Forschende suchen diese Struktur schon seit über 40 Jahren. Wie die sogenannte „Feder im Ohr“ das #Hören steuert: https://www.uni-goettingen.de/de/3240.html?id=7735

Forschung in #NatureNeuroscience: https://doi.org/10.1038/s41593-024-01849-3

#neurobiologie #neurowissenschaften #neuro #biologie

Presseinformationen - Georg-August-Universität Göttingen

Webseiten der Georg-August-Universität Göttingen

Georg-August Universität Göttingen
Long-term memory (LTM) does not require the formation of short-term memory (STM), and CaMKII-dependent plasticity specifically regulates STM for avoidance memory. #NatureNeuroscience www.nature.com/articles/s41...

Formation of long-term memory ...
#NatureNeuroscience Membrane mechanics dictate axonal pearls-on-a-string morphology and function https://www.nature.com/articles/s41593-024-01813-1 #ScienceNews Controversial study redraws classical picture of the neuron in mouse. It suggests “pearling” of axons may help signaling https://www.science.org/content/article/controversial-study-redraws-classical-picture-neuron "Unmyelinated axons of the mouse brain have nonsynaptic, nanoscopic varicosities ~200 nm in diameter repeatedly along their length interspersed with a thin cable ~60 nm in diameter like pearls-on-a-string. This axon nanopearling can be explained by membrane mechanical properties. Neuronal activity modulates plasma membrane cholesterol concentration, leading to changes in axon nanopearls and causing slowing of action potential conduction velocity. Biophysical forces dictate axon morphology and function, and its modulation underlies axonal plasticity."
Membrane mechanics dictate axonal pearls-on-a-string morphology and function - Nature Neuroscience

Axons have always been assumed to be cylindrical. Using in silico modeling and cryopreservation of tissues, Griswold et al. demonstrate that unmyelinated axons of the mammalian central nervous system exhibit pearls-on-a-string morphology through their entire length.

Nature

CONTROVERSIAL STUDY ON SELF-CLEANING BRAINS
Mastodon Post

The British Psychological Society

New sleep study ignites brain cleaning controversy

Recent work challenges ideas of increased toxin clearance during sleep — though some researchers question the study’s methods.

19 June 2024
By Emma Young

https://www.bps.org.uk/research-digest/new-sleep-study-ignites-brain-cleaning-controversy

Credit where credit is due: I learned of this study from NPR. NPR has a good mobile app.

:

#alzheimers #alzheimersdisease #andaweimiao #billwisden #dementiaresearch #dementiaresearchinstitute #glymphatic #glymphaticsystem #glymphaticsystemhypothesis #imperialcollegelondon #maikennedergaard #medicalscience #medicalsciencenews #nationalpublicradio #natureneuroscience #nickfranks #npr #radio #radiomobileapp #radiomobileapps #science #sciencenews #sleepstudies #sleepstudy #toxinclearance #toxinclearanceduringsleep

:::

New sleep study ignites brain cleaning controversy | BPS

Recent work challenges ideas of increased toxin clearance during sleep — though some researchers question the study’s methods.

BPS
Sleep does not help brain wash out toxins, study suggests

Finding that clearance of fluid in mice brains is lower in sleep and anaesthesia runs counter to dominant view in neuroscience

The Guardian

So excited to share chapter 2 of my dissertation, published today in #NatureNeuroscience. We used movie to capture how the brain represents emotion concepts (e.g., angry, sad, happy, etc) in 5-to-15-year-old children. Two main findings:
First, each emotion is represented in a distinct way across the brain.
Second, activation more broadly synchronizes with age, suggesting that we develop a shared interpretation of emotion cues across adolescence. #neuroscience #science

https://rdcu.be/dd4M1

It's been 1 yr since #NatureNeuroscience announced their #OpenAccess fee of €9,500/US $11,390/£8,290 (the choice of listing only those 3 currencies is arbitrary and not necessarily an indicator of where the money will likely come from, right??).

This is, in the words of Dr. Glaucomflecken, academic #journals doing #crime
https://www.youtube.com/watch?v=8F9gzQz1Pms

Nature Neuroscience offers open access publishing - Nature Neuroscience

The authors of primary research papers accepted by our journal have the opportunity to make their work freely available to all upon publication.

Nature