Giuseppe MichieliDual-Route #H5N1 #Vaccination Induces Systemic and #Mucosal #Immunity in Murine and Bovine Models, https://etidiohnew.blogspot.com/2025/09/dual-route-h5n1-vaccination-induces.html
Chapter One - #Mucosal #Sudan virus #infection results in a lethal disease in #ferrets with previous #Lloviu virus infection not providing cross-protection, https://etidiohnew.blogspot.com/2025/07/chapter-one-mucosal-sudan-virus.html
A trivalent #mucosal #vaccine encoding phylogenetically inferred ancestral #RBD #sequences confers pan- #Sarbecovirus #protection in mice https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00403-7?rss=yes
Case et al. use ancestral phylogenetic reconstructions of Sarbecovirus sequences to generate a pan-Sarbecovirus vaccine. In mice, vaccine confers protection vs all tested Sarbecoviruses, including #SARS-CoV, multiple SARS-CoV-2 #variants, & pre-emergent Sarbecovirus strains.
JNSLCT
#Intranasal M2SR (#M2-deficient Single Replication) #Influenza #Vaccine Induces Broadly Reactive #Mucosal #Antibody Production in Adults, J Infect Dis.: https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiae361/7714804?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=jid&utm_medium=email
These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.
Maxi 12x 💉Hier habe ich alle meine recherchierten Quellen zu #StreptococcusSalivarius #K12 gegen #Corona zusammengetragen:
https://pastebin.hot-chilli.net/?0b3ce182e423df09#4kFQvggKB9pudVE2bSCRXZ4sgHSuviMxvGAMcd75xw6b #Covid #SARSCoV2 #S_Salivarius #mucosal #Schleimhautimmunität
Respiratory #mucosal immune #memory to #SARS-CoV-2 after #infection and #vaccination, Nat Commun.: https://www.nature.com/articles/s41467-023-42433-w #research #vaccines #covid19 #immunity
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination - Nature Communications
Evidence from animal models suggest a vital role for mucosal vaccination in inducing protection from coronavirus infection. Here the authors examine the B and T cell responses at the lower airways, and contrast humoral and cellular immunity of people after infection and vaccination.
#Mucosal and #Serum #Antibodies 3 Weeks after Symptomatic #BA286 #Infection, October 26, 2023, N Engl J Med 2023; 389:1626-1628,
DOI: 10.1056/NEJMc2310347 #covid19 #SARS_COV_2 #research #immunity
DOI: 10.1056/NEJMc2310347 #covid19 #SARS_COV_2 #research #immunity
#Mucosal #vaccines for #SARS-CoV-2: scientific #gaps and opportunities — #workshop report https://www.nature.com/articles/s41541-023-00654-6
Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report - npj Vaccines
On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The Coalition for Epidemic Preparedness Innovation (CEPI), The Bill & Melinda Gates Foundation (BMGF), The Biomedical Advanced Research and Development Authority (BARDA), and the Wellcome Trust hosted a virtual workshop entitled “Mucosal Vaccines for SARS-CoV-2: Scientific Gaps and Opportunities.” During the workshop, researchers and vaccine developers from around the world discussed the potential of mucosal vaccines to block SARS-CoV-2 transmission and reviewed the status of SARS-CoV-2 mucosal vaccine research. Here, we summarize key challenges and opportunities in basic, translational, and clinical research that were highlighted during the meeting. We also provide recommendations to advance the field and accelerate the development of mucosal vaccines for SARS-CoV-2.
danielPromises and challenges of #mucosal #COVID19 vaccines
"Several mucosal vaccines are currently being developed with the aim of inducing long-lasting protective immune responses at the mucosal sites where #SARSCoV2 infection begins"
via @AlexPed
https://www.sciencedirect.com/science/article/pii/S0264410X23003961?dgcid=rss_sd_all