@mediaevalfishsandwich Still hunting for that stronger "like" than "like" for "thank you that was very informative": that's a great paper!!
RBD-ACE2 binding affinity ... BA.3.2 exhibits disastrously low fitness compared to LP.8.1.1
and in human plasma
in human plasma, BA.3.2 also demonstrated profound humoral immune evasion, with an 11-fold reduction in geometric mean neutralizing titer (NT50) compared to BA.3
and re: what the smarties in the xcancel thread were saying about China's different immune landscape:
Class 1/4 antibodies are prevalent in Chinese populations immunized with inactivated vaccines, where immune imprinting is less pronounced In contrast, mRNA vaccine recipients with stronger immune imprinting rarely develop these antibodies, which may cause divergent neutralization responses against BA.3.2 between these groups.
Figure 3 of that paper, too - very informative!
#COVID #COVID19 #SARSCoV2 #BA32 #immunology