Giuseppe MichieliAn #intranasal adjuvanted, recombinant #influenza A/ #H5 #vaccine primes against diverse #H5N1 clades: a phase I trial, https://etidiohnew.blogspot.com/2025/11/an-intranasal-adjuvanted-recombinant.html
A single-dose #intranasal #immunization with a novel #bat #influenza A virus-vectored #MERS #vaccine provides effective protection against lethal MERS-CoV challenge, https://etidiohnew.blogspot.com/2025/07/a-single-dose-intranasal-immunization.html
Immunogenicity and protective #efficacy of an #intranasal NA-based #influenza virus #vaccine adjuvanted ..., https://etidiohnew.blogspot.com/2025/02/immunogenicity-and-protective-efficacy.html
Joe VilasLooking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying.
https://scitechdaily.com/needle-free-new-nano-vaccine-effective-against-all-covid-19-variants/
https://onlinelibrary.wiley.com/doi/10.1002/advs.202404159
https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202404159
#Intranasal #hemagglutinin protein #boosters induce robust mucosal #immunity and cross-protection against #influenza A viral challenge
Source: BioRxIV, AbstractLicensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to the lack of local mucosal immune responses. Here, we describe intranasal booster strategy with unadjuvanted recombinant hemagglutinin (HA)…
#Intranasal #hemagglutinin protein #boosters induce robust mucosal #immunity and cross-protection against #influenza A viral challenge
Source: BioRxIV, AbstractLicensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to …
A single-dose #intranasal live-attenuated codon deoptimized #vaccine provides broad #protection against #SARS-CoV-2 and its #variants, Nat Commun.: https://www.nature.com/articles/s41467-024-51535-y
Current SARS-CoV-2 vaccines require several injections for optimal immune protection. Here, the authors report an intranasal live-attenuated vaccine that induces long-term immunity following a single dose and protects from SARS-CoV-2 wildtype and variants in non-human primate and small animal models.
A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants - Nature Communications
Current SARS-CoV-2 vaccines require several injections for optimal immune protection. Here, the authors report an intranasal live-attenuated vaccine that induces long-term immunity following a single dose and protects from SARS-CoV-2 wildtype and variants in non-human primate and small animal models.
#Intranasal administration of 8-valent next-generation #flu #vaccine elicits protective immune responses vs seasonal and #prepandemic viruses, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00354-24?af=R
8-valent COBRA vaccine elicited #antibodies that recognized a broad panel of strains representing different subtypes, & these vaccinated animals were protected vs flu virus challenges. This study demonstrated that mixture of 8 COBRA HA/NA proteins mixed with an intranasal adjuvant is a promising candidate vaccine.
#Intranasal M2SR (#M2-deficient Single Replication) #Influenza #Vaccine Induces Broadly Reactive #Mucosal #Antibody Production in Adults, J Infect Dis.: https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiae361/7714804?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=jid&utm_medium=email
These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.
An #intranasal live-attenuated #SARS-CoV-2 #vaccine limits virus #transmission https://www.nature.com/articles/s41467-024-45348-2
An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission - Nature Communications
In this study, the authors evaluated the protective capacity of a mucosal, live-attenuated SARS-CoV-2 vaccine and show that it induces systemic and mucosal humoral immunity, protects from clinical disease symptoms, and prevents virus transmission in hamsters more efficiently than an intramuscular mRNA vaccine.
Helen BranswellThis could be pretty interesting: AstraZeneca, which makes the #intranasal flu vaccine #FluMist, has applied to #FDA to allow the vaccine to be administered at home, by adults eligible to get it or old enough to give it to eligible kids. Decision pending; watch this space. https://www.statnews.com/2023/10/24/astrazeneca-maker-of-flumist-seeks-to-allow-at-home-administration-of-vaccine/
