CellBioNewsMay 25, 2024

Researchers reveal how #acetylation regulates #centromere dynamics, #chromosome #segregation and #mitotic progression.

#TIP60 #Bub1

https://phys.org/news/2024-05-reveal-acetylation-centromere-dynamics-chromosome.html

Researchers reveal how acetylation regulates centromere dynamics, chromosome segregation and mitotic progression

Cell division produces new cells, which underpin life proliferation and development. Mitosis is the shortest and the most dynamic phase of the cell cycle. During mitosis, chromosomes are evenly distributed between the two daughter cells, preserving the integrity of the genome.

Phys.org
micrordtApr 27, 2024

Understanding Spermatogenesis: The Journey of Sperm Production

#AcrosomalPhase, #CapPhase, #Fertilization, #GolgiPhase, #MaturationPhase, #Meiosis, #Mitotic, #Sperm #CellBiology, #MenHealth Spermatogenesis is a complex biological process essential for the continuous production of male gametes, known as spermatozoa or sperm. It is a tightly regulated process that occurs within the seminiferous tubules…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read…

https://micrordt.wordpress.com/2024/04/27/understanding-spermatogenesis-the-journey-of-sperm-production/

Understanding Spermatogenesis: The Journey of Sperm Production

#AcrosomalPhase, #CapPhase, #Fertilization, #GolgiPhase, #MaturationPhase, #Meiosis, #Mitotic, #Sperm #CellBiology, #MenHealth Spermatogenesis is a complex biological process essential for the cont…

Medical Microbiology & RDT Labs
The EMBO JournalJun 27, 2023

Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation

https://www.embopress.org/doi/10.15252/embj.2022112847

The EMBO JournalApr 13, 2023

How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies

https://www.embopress.org/doi/10.15252/embj.2022111559

CellBioNewsFeb 24, 2023

#Mitotic #chromosome condensation contributes to the homeostatic control of #gene #expression #regulation.

https://phys.org/news/2023-02-mitotic-chromosome-condensation-contributes-homeostatic.html

Mitotic chromosome condensation contributes to the homeostatic control of gene expression regulation

In a collaborative paper in published in the Proceedings of the National Academy of Sciences, Yves Barral with Jorrit Enserink and the Pierre Chymkowitch group in Norway show that the effects on transcription of chromosome condensation during mitosis is not just a passive phenomenon, but has strong biological significance: It resets the transcriptome to protect cells from uncontrolled transcriptional drift during the following interphase. Thereby, it contributes to the homeostatic control of gene expression regulation.

Phys.org