A #CRISPR-Cas9-tagging approach to induce #chromosome-specific segmental #aneuploidies: targeted assembly of ectopic #kinetochores at endogenous repeats - a way to recapitulate and study specific disease-associated #missegregation events in human cells
@McClellandLab
https://www.embopress.org/doi/10.15252/embj.2022111587
How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies
How do #yeast cells adapt to high rates of #chromosome #missegregation?
Chris Campbell and coworkers @maxperutzlabs define serial alterations from specific #aneuploidies, #karyotype refinement, point #mutations, to loss of beneficial copy number alterations
The EMBO Journal