This seems significant. Note: mouse model.

A smart molecule beats the mutation behind most pancreatic cancer
https://www.sciencedaily.com/releases/2024/03/240305134402.htm

Researchers have designed a candidate drug that could help make pancreatic cancer, which is almost always fatal, a treatable, perhaps even curable, condition.

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D
https://www.nature.com/articles/s41589-024-01565-w

#cancer #PancreaticCancer #oncogenesis #KRas #KRasG12D #ras #chemotherapy

Mistigram: this texty screen, a touch of Bosch at the beach, is the handiwork of @adelfaure , designed as album art for #EarthlyDelight by #Oncogenesis. This piece was included in the new music-themed MIST0224 artpack collection.

https://mistfunk.wordpress.com/2024/02/29/mist0224-adel_faure-oncogenesis-earthly_delight/

#adelFaure #beach #heatwave #MIST0224 #oncogenesis #pollution #textmode

"Here, we demonstrate that the #midbody (MB) matrix is the site of ribonucleoprotein assembly and is enriched in mRNAs that encode proteins involved in cell fate, #oncogenesis, and #pluripotency, which we are calling the MB granule. Both MBs and post-abscission MBRs are sites of spatiotemporally regulated translation, which is initiated when nascent daughter cells re-enter G1 and continues after #extracellular release"

https://www.sciencedirect.com/science/article/pii/S153458072300357X?via%3Dihub

How do cancer-specific chromosome gains/losses contribute to #oncogenesis?
Susanne Lens and collaborators at UMC Utrecht describe a #kinesin-based strategy for inducing #mitotic #missegregation of selected #chromosomes, as tool for modeling specific #aneuploidies

https://www.embopress.org/doi/10.15252/embj.2022111559