The article explains how genetic differences influence brain structure, and how these structural variations relate to autism and attention disorders. It uses large genetic datasets to link specific brain regions and white matter pathways with the risk of these conditions, suggesting anatomy may precede symptom development.

This topic is of interest to psychology because it connects neural structure with behavioral outcomes, offering insight into how biology can shape cognitive and social functioning across development.

Article Title: Genetic data reveals how brain structure contributes to autism and attention disorders

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/genetic-data-reveals-how-brain-structure-contributes-to-autism-and-attention-dis/

#Neurostructure #Autism #ADHD #Neurodevelopment #Genetics #BrainImaging #FrontalLobe #WhiteMatter #MendelianRandomization #PsychologyResearch

STATGEN 2024 talk
Identifying GxE through Mendelian Randomization
Xiaofeng Zhu

Statistical power is low and detecting GxE is a challenge.

See:

Aschard H. A perspective on interaction effects in genetic association studies. Genet Epidemiol. 2016 Dec;40(8):678-688. doi: 10.1002/gepi.21989. Epub 2016 Jul 7. PMID: 27390122; PMCID: PMC5132101.

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#Genetics #STATGEN2024 #StatisticalGenetics #MendelianRandomization

STATGEN 2024 talk
An efficient method for network Mendelian randomization allows network structure discovery and effect estimation.
Jean Morrison

Existing methods

* GenomicSEM
* Network deconvolution
Graph-cML
bimmer

Our method

* Network empirical shrinkage Mendelian randomization (NESMR)
- likelihood-based

Assumptions
1. Causal effects between traits are linear with no interactions

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#Genetics #MendelianRandomization #STATGEN2024 #StatisticalGenetics

STATGEN 2024
Pleiotropy-robust methods for high-dimensional multivariable Mendelian randomization (HDMR)
Nathan LaPierre presenting, co-authors: Matthew Stephens, Xin He

In HDMR, we have many genetically correlated exposures, which may be explained by unobserved shared factors. These can be inferred by factor analysis.

Flexible, modular framework: Factor-Augmented MR
1. Factor Analysis
2. Regression/Variable Selection

#Genetics #StatisticalGenetics #MendelianRandomization #STATGEN2024

Does what you eat affect how you feel? https://www.nationalelfservice.net/?p=169039

Daisy Crick summarises a recent paper on the casual relationship between polyunsaturated fatty acids and depression. 

#Diet #Depression #Omega3 #Omega6 #FattyAcids #MendelianRandomization

#BloodPressure Highly Likely to Cause #Neurotic Personality Trait - https://neurosciencenews.com/blood-pressure-neuroticism-21906/… via
@neurosciencenew

#MendelianRandomization #Psychiatry

"#diastolic blood pressure was significantly associated with #neuroticism (over 90%), based on 1074 #SNP's."