Mastodawn

#psychedelics #psychedelicresearch #ketamine efficacy and safety in #palliativecare the #er and the #icu leading to less #existentialdread #pain and the possibility of #esketamine leading to a #mysticalexperience which may improve outcomes and #reducesuffering #psychedelicmentalhealth https://psychedelicmentalhealth.net/psychedelics-in-palliative-care-ready-for-primetime-making-the-case-for-ketamine-assisted-psychotherapy-horowitz-et-al-2024/

Spotlight: Psychedelics in Palliative Care, Ready for Primetime! Making the Case for Ketamine-Assisted Psychotherapy (Horowitz, et al, 2024)

"Preliminary evidence demonstrates that Ketamine-Assisted Psychotherapy (KAP) can significantly improve depression, demoralization and existential distress in seriously ill people"

Psychedelic Mental Health Institute

Psychedelic Mental Health 23h ago

https://pubmed.ncbi.nlm.nih.gov/41987516/ #ketamine for acute pain in older adults in the er (2026) #esketamine

Acute pain management in older adults presenting to the emergency department: a clinical review - PubMed

Managing acute pain in older adults is a complex challenge in emergency care, influenced by age-related physiological changes, multimorbidity and altered pharmacokinetics. Inadequate treatment contributes to frailty, delirium, functional decline and reduced quality of life, yet oligoanalgesia remain …

PubMed

Psychedelic Mental Health 1d ago

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2847667 #Ketamine and #esketamine can be tested as active placebos and administered in all the ways other psychedelic medicines are. These medicines are FDA approved and have been studied for 60+ years. Compare #psychedelics in a double blind study with ketamine. Wild that this isn’t the common approach in #psychedelicresearch

Psychedelic Mental Health 1d ago

https://pubmed.ncbi.nlm.nih.gov/41989186/ Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes (Patel, et al, 2026) “Subanesthetic ketamine improved specific depressive symptoms in critically ill ICU patients without significant hemodynamic instability. These findings support its potential as a rapid-acting antidepressant in the ICU, warranting further prospective trials.” #ketamine #ketaminesafety #icu #mentalhealth

Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes - PubMed

BackgroundKetamine has demonstrated efficacy in treatment-resistant depression, primarily in psychiatric or outpatient populations. Its use in ICU patients remains underexplored, with limited data beyond case reports and small series. This study evaluated the association between subanesthetic ketami …

PubMed

Psychedelic Mental Health 5d ago

A Systematic Review and Meta-Analysis of the Efficacy and Safety of Intranasal Esketamine for Rapid Symptom Relief in Treatment-resistant Depression (Saun, et al, 2026) https://pubmed.ncbi.nlm.nih.gov/41968732/ These findings support intranasal esketamine as a rapidly acting intervention for TRD, consistent with emerging evidence on glutamatergic modulation. #ketamine #esketamine #psychedelics #depression #spravato

A Systematic Review and Meta-Analysis of the Efficacy and Safety of Intranasal Esketamine for Rapid Symptom Relief in Treatment-resistant Depression - PubMed

Esketamine demonstrates efficacy in achieving rapid relief of depressive symptoms in TRD, but findings must be interpreted with caution, given the heterogeneity and adverse event profile. Further high-quality, long-term studies are warranted to establish sustained efficacy and safety.

PubMed

Psychedelic Mental Health 5d ago

https://pubmed.ncbi.nlm.nih.gov/41968009/ Serotonergic and glutamatergic mechanisms converge in ketamine's rapid responses (Fogaça, 2026) These findings suggest convergent serotonergic and glutamatergic pathways underlying ketamine's antidepressant effects. #ketamine #psychedelics #depression #serotonin

Serotonergic and glutamatergic mechanisms converge in ketamine's rapid responses - PubMed

Ketamine's rapid antidepressant actions are commonly attributed to glutamatergic mechanisms. In a recent study, Luo and colleagues have shown that ketamine inhibits the serotonin transporter and that prefrontal serotonergic signaling synergizes with NMDA receptor blockade to recruit vasoactive intes …

PubMed

MindTGap 5d ago

Just Up the Dose?: Therapy Cults are Influencing Psychedelic Medicine Standards
#Psymposia #Neşe
Apr 13, 2026
#ketamine #redflag #therapy #cults #therapycult #maps #lycos #billionaires #techbros are #candyflipping
https://www.youtube.com/watch?v=ueaXiJYyQ3w

Just Up the Dose?: Therapy Cults are Influencing Psychedelic Medicine Standards

YouTube

CosmicSpirit🆓-VG🌱6d ago

#ketamine #drugs #microscope

Psychedelic Mental Health Apr 10

https://pubmed.ncbi.nlm.nih.gov/41955843/ #ketamine #esketamine #psychedelics in the treatment of #borderlinepersonalitydisorder #mentalhealth

Psychedelics as a potential treatment for borderline personality disorder: A narrative review - PubMed

Borderline personality disorder (BPD) is a serious mental illness with high rates of morbidity and stigma; however, successful remission is frequently limited by a paucity of accessible treatment options. In an era of growing interest in psychedelics as novel psychiatric treatment modalities, patien …

PubMed

Psychedelic Mental Health Apr 10

New Preprint paper suggests #esketamine (#spravato) a variant of #ketamine is a #psychedelic that causes mystical experiences which are related to therapeutic outcome in a real world, observational long term study https://pubmed.ncbi.nlm.nih.gov/41959772/

Mystical Experience Induced by Esketamine Treatment: A Real-World Observational Study - PubMed

Esketamine is a fast-acting antidepressant drug which induces acute psychoactive effects. The most frequent is a dissociative state which seems unrelated to therapeutic efficacy. Other esketamine-induced effects, including psychedelic-like mystical experiences, have been poorly studied in terms of p …

PubMed