Mastodawn

https://pubmed.ncbi.nlm.nih.gov/41873584/ #esketamine #ketamine #brains

Cognitive Effects of Esketamine in Treatment-Resistant Depression: A Systematic Review - PubMed

Current evidence, albeit limited, suggests that esketamine appears to be cognitively safe in adults with treatment-resistant depression and may confer selective improvements, particularly in attention and processing speed, with more variable benefits in memory and executive functioning over sustaine …

PubMed

Psychedelic Institute 12h ago

Ketamine-induced changes in accumbal glutamate and their association with altered states of consciousness (2026) “individual glutamate changes induced by #ketamine correlate with anxious ego dissolution and reductions in vigilance, indicating that ketamine-induced glutamate alterations in the NAc underly specific alterations in perception and consciousness.” https://pubmed.ncbi.nlm.nih.gov/41871813/ #brains #psychedelics

Ketamine-induced changes in accumbal glutamate and their association with altered states of consciousness - PubMed

Ketamine has been shown to modulate glutamate signaling in animals and may therefore have the potential to restore glutamate imbalances in the brain. Impaired glutamate homeostasis has been implicated in mental health disorders such as substance use disorders (SUDs). Thus, we investigated ketamine's …

PubMed

Psychedelic Institute 1d ago

https://pubmed.ncbi.nlm.nih.gov/41869093/ #ketamine

Ketamine Use for ED Sedation: Pharmacologic Basis, Clinical Applications, and Safety Considerations - PubMed

Ketamine is a versatile pharmacologic agent whose unique receptor interactions explain its broad applicability in emergency medicine. Its primary mechanism of action is non-competitive antagonism of N-methyl-D-aspartate (NMDA) receptors, which underlies its dissociative, anesthetic, and analgesic pr …

PubMed

Psychedelic Institute 2d ago

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach (Agnorelli, et al, 2026) " By linking molecular, cellular and network-level changes, our results point to the DMN as a central hub where ketamine may reshape brain hierarchies in the long term, providing new directions for understanding its therapeutic mechanisms and developing targeted treatments." #ketamine #psychedelics #brains https://pubmed.ncbi.nlm.nih.gov/41863255/

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach - PubMed

We investigated ketamine's neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/kg, intravenous). Eleven male participants underwent two PET/M …

PubMed

Psychedelic Institute 4d ago

https://pubmed.ncbi.nlm.nih.gov/41858652/ #ketamine #bipolar #depression #esketamine #psychedelics

Ketamine as an NMDA-modulating therapy in bipolar disorder: rationale and evidence - PubMed

Ketamine and esketamine represent mechanistically novel and clinically effective treatments for bipolar depression. Their rapid antidepressant action and low switch liability distinguish them from traditional antidepressants. Esketamine, with its favorable tolerability and intranasal administration, …

PubMed

Psychedelic Institute 5d ago

https://www.sciencedaily.com/releases/2026/03/260307213234.htm#google_vignette #ketamine

Brain scans reveal how ketamine quickly lifts severe depression

A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression. Researchers tracked changes in a critical brain receptor that helps neurons communicate and found that ketamine reshapes its activity in specific brain regions tied to mood and reward. These shifts strongly matched improvements in patients’ symptoms. The findings could help scientists develop better ways to predict who will benefit from ketamine therapy.

ScienceDaily

Psychedelic Institute 6d ago

Oligarchs restrict access to healthcare services that benefit the oligarchy. #ketamine is a well-studied, generic medicine, prescribed in a variety of routes of administrations and patient settings, indicated in a number of pain and mental health conditions, with ongoing, rigorous study since first synthesized in 1962. The misuse of this medicine does not negate that it has been safely administered in billions of people and animals with no lasting harms. Telehealth is healthcare.

Kerry Mitchell 🍁6d ago

The normal mode for a lot of Americans seems to be a near constant experience of stress or trauma accompanied by medication. There are an amazing number of people who want something to take to make themselves feel better. The use of Ketamine has seen an 8 times increase in the U.S. since it was approved for treating depression and over 1 million Americans take it. Often, it’s prescribed without a doctor visit through online providers. https://wallstreetjournal-ny.newsmemory.com/?publink=122bb1a88_1352002 #depression #ketamine

The ‘Wild West’ Of Ketamine

Tricia Anne Dewey struggled for many years with domestic violence and

Psychedelic Institute 6d ago

Researchers write “A sample of 11,441 patients was analyzed, At-home, telehealth-supported ketamine administration was largely safe, well-tolerated, and associated with improvement in patients with depression. Strategies for combining psychedelic-oriented therapies with rigorous telehealth models, as explored here, may uniquely address barriers to mental health treatment.” https://psychedelicmentalhealth.net/psychedelic-therapy-cognitive-behavioral-therapy-ketamine-context-competencies/ #ketamine #mentalhealth #psychedelics #ketaminetherapy #harmreduction #psychedelicinstituteproject

Psychedelic Cognitive Behavioral Therapy: On Ketamine, Context, and Competencies in "Assisted-Psychotherapy”

There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.

Psychedelic Institute - Psychedelics in Mental Health

Psychedelic Institute 6d ago

Intranasal esketamine: real-world clinical practice in treatment-resistant depression and factors associated with treatment response (Baune, et al, 2026) https://link.springer.com/article/10.1186/s12888-026-07980-8 #mentalhealth #depression #esketamine #spravato #psychedelics #ketamine