Mastodawn

Psilocybin and the Exploration of Mystical and Psi Experiences: Clinical and Spiritual Implications
with J. Kim Penberthy, Ph.D., ABPP https://www.theosophical.org/workshops/psilocybin-and-the-exploration-of-mystical-and-psi-experiences-clinical-and-spiritual-implications #psilocybin #mushrooms #psychedelics #ketamine #consciousness #psychedelic

Psilocybin and the Exploration of Mystical and Psi Experiences: Clinical and Spiritual Implications

with J. Kim Penberthy, Ph.D., ABPP Psilocybin, a naturally occurring psychedelic, has been shown to reliably induce profound mystical-type and...

Theosophical Society in America

Psychedelic Institute Project 1d ago

https://pubmed.ncbi.nlm.nih.gov/41894542/ #ketamine

Ketamine as a Rapid-Acting Antidepressant: A Scoping Review of Mechanisms and Efficacy in Treatment-Resistant Depression - PubMed

Ketamine displays rapid onset and high efficacy in the management of TRD; nevertheless, its long-term safety, risk of dependence, and potential cognitive effects necessitate close clinical monitoring. Future research should prioritize the exploration of synergistic treatment regimens and the develop …

PubMed

Psychedelic Institute Project 2d ago

https://pubmed.ncbi.nlm.nih.gov/41890575/ Oral Ketamine for Chronic Pain: Towards an Evidence-Based Dosing Regimen (Winegarden, et al, 2026) #ketamine #chronicpain #psychedelics #ketaminetherapy

NieuwsJunkies.nl 2d ago

📰 Nederlandse (19) die koffer vol drugs VS in wilde smokkelen, vastgezet door ICE

https://nieuwsjunkies.nl/artikel/1AFm

🕤 09:32 | RTL Nieuws
🔸 #Immigratie #Drugs #Ketamine #ICE #Arrestatie

Nederlandse (19) die koffer vol drugs VS in wilde smokkelen, vastgezet door ICE

Een 19-jarige Nederlandse vrouw die in oktober heeft geprobeerd om 76 kilo ketamine de Verenigde Staten in te smokkelen, zit vast in een detentiecentrum van immigratiedienst ICE. De vrouw zou volgens de regionale zender Oost een deal met justitie hebben gesloten om zo een kortere straf te krijgen, maar mag dus alsnog het land niet uit.

RTL Nieuws

Psychedelic Institute Project 3d ago

https://pubmed.ncbi.nlm.nih.gov/41876451/ #ketamine #ptsd #psychedelics #psychedelicresearch

Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD - PubMed

Ketamine holds promise for the treatment of post-traumatic stress disorder (PTSD), but challenges remain in delivery and sustained effects. This controlled study evaluates a novel intranasal formulation, employing AmyloLipid nanovesicles (ALN) to enhance ketamine's therapeutic efficacy in a predator …

PubMed

Psychedelic Institute Project 3d ago

https://pubmed.ncbi.nlm.nih.gov/41878960/ #psychedelics #ketamine #mentalhealth #psilocybin

[Perspectives opened up by the physiopathological understanding of psychiatric disorders] - PubMed

Neuroimaging techniques have a rightful place in the field of psychiatry. They are essential for differential diagnosis, especially when the psychiatric presentation is atypical. Furthermore, they associate brain dysfunction with psychiatric disorders, but they cannot yet provide a definitive psychi …

PubMed

Psychedelic Institute Project 3d ago

https://pubmed.ncbi.nlm.nih.gov/41879399/ #mtor #esketamine #ketamine #ageing

Esketamine and postoperative cognitive dysfunction in aged mice: Role of the SIRT3/AMPK/mTOR pathway - PubMed

Esk appears to regulate SIRT3/AMPK/mTOR pathway to inhibit neuroinflammation and improve mitochondrial dysfunction, thereby mitigating POCD in aged mice.

PubMed

Psychedelic Institute Project 3d ago

https://pubmed.ncbi.nlm.nih.gov/41878960/ #ketamine #brains #neuroscience

[Perspectives opened up by the physiopathological understanding of psychiatric disorders] - PubMed

PubMed

Psychedelic Institute Project 3d ago

https://www.nature.com/articles/s41386-020-0644-9 #ketamine #mtorc1 #depression

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin - Neuropsychopharmacology

Twenty-four hours after administration, ketamine exerts rapid and robust antidepressant effects that are thought to be mediated by activation of the mechanistic target of rapamycin complex 1 (mTORC1). To test this hypothesis, depressed patients were pretreated with rapamycin, an mTORC1 inhibitor, prior to receiving ketamine. Twenty patients suffering a major depressive episode were randomized to pretreatment with oral rapamycin (6 mg) or placebo 2 h prior to the intravenous administration of ketamine 0.5 mg/kg in a double-blind cross-over design with treatment days separated by at least 2 weeks. Depression severity was assessed using Montgomery–Åsberg Depression Rating Scale (MADRS). Rapamycin pretreatment did not alter the antidepressant effects of ketamine at the 24-h timepoint. Over the subsequent 2-weeks, we found a significant treatment by time interaction (F(8,245) = 2.02, p = 0.04), suggesting a prolongation of the antidepressant effects of ketamine by rapamycin. Two weeks following ketamine administration, we found higher response (41%) and remission rates (29%) following rapamycin + ketamine compared to placebo + ketamine (13%, p = 0.04, and 7%, p = 0.003, respectively). In summary, single dose rapamycin pretreatment failed to block the antidepressant effects of ketamine, but it prolonged ketamine’s antidepressant effects. This observation raises questions about the role of systemic vs. local blockade of mTORC1 in the antidepressant effects of ketamine, provides preliminary evidence that rapamycin may extend the benefits of ketamine, and thereby potentially sheds light on mechanisms that contribute to depression relapse after ketamine administration.

Nature

Psychedelic Institute Project 3d ago

https://psychedelicmentalhealth.net/spotlight-n-n-dimethyltryptamine-elicits-antidepressant-and-anxiolytic-effects-in-helpless-mice-a-comparative-study-with-s-ketamine-da-sousa-silva-et-al-2026/ Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)
#DMT compared with #ketamine variant, #esketamine in mice. #depression #anxiety #psychedelics #psychedelic #psychedelicresearch

Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)

DMT compared with ketamine variant, esketamine in mice.

Psychedelic Institute - Psychedelics in Mental Health