Psychedelic Institute ProjectMechanism of antidepressant action of ketamine and differences between its two enantiomers (Zhan, et al, 2026) https://pubmed.ncbi.nlm.nih.gov/41929374/ #ketamine #depression #mentalhealth #psychedelics
Ketamine as a potential cognitive enhancer in neurological disorders: evidence from preclinical and clinical studies (Rojas, et al, 2026) https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1786249/full #ketamine #brains #mentalhealth #traumaticbraininjury #neuroscience #psychedelics
Ketamine May Fight Chronic Fatigue, Study Suggests. (2026) https://clinicaltrials.rbhs.rutgers.edu/news/ketamine-may-fight-chronic-fatigue-study-suggests/ “Ketamine’s effects in 10-participant clinical trial minimally outperformed an active placebo that unexpectedly exhibited its own antifatigue action. However, participants who received a single low-dose infusion of ketamine experienced a sufficient energy boost to justify further study. For a symptom that has long resisted intervention, even a minor signal is noteworthy.” #ketamine #chronicfatigue #mentalhealth
Ketamine May Fight Chronic Fatigue, Study Suggests. - | New Jersey Alliance for Clinical and Translational Science | NJ ACTS
Ketamine, a decades-old anesthetic and fast-acting treatment for severe depression, may also offer some people rapid relief from chronic fatigue, according to a small proof-of-concept study led by researchers at Rutgers Health […]
Subanesthetic #ketamine for Chronic Non-Cancer Pain: A Systematic Review of Evidence from Randomized Trials over the Past Two Decades (Zavaleta-Monestel, et al, 2026) “Overall, ketamine demonstrated significant short-term pain relief (p < 0.05), particularly in neuropathic conditions; however, the magnitude of this effect decreased progressively after the infusion ended. Reported adverse effects were mild and transient, with no evidence of severe toxicity.” https://www.mdpi.com/2813-1851/5/2/10 #chronicpain
The impact of ketamine on posttraumatic stress disorder (PTSD) symptomatology in trauma-exposed populations: a narrative review (Malik, et al, 2026) "Clinical trials suggest that a single intravenous infusion of ketamine (0.5 mg/kg) may significantly reduce PTSD symptoms within 24 hours” https://pubmed.ncbi.nlm.nih.gov/41922107/ #ptsd #ketamine #mentalhealth #psychedelics #ketaminetherapy
The impact of ketamine on posttraumatic stress disorder (PTSD) symptomatology in trauma-exposed populations: a narrative review - PubMed
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used in trauma and emergency medicine for its rapid analgesic and sedative properties. While its efficacy in acute pain management is well established, concerns persist regarding its long-term psychological effects, particularly …
Ketamine for negative and depressive symptoms in schizophrenia: the evidence so far (Diendorfer, et al, 2026 https://pubmed.ncbi.nlm.nih.gov/41918583/ #ketamine #psychedelics #depression #schizophrenia #ketaminetherapy #mentalhealth
Psychotherapy Commission ACPEThis brief highlights a growing debate about integrating psychosocial supports with pharmacologic treatment for mood disorders. The content is relevant to mental health practitioners because it points to potential benefits of pairing ketamine administration with psychotherapy or monitoring, suggesting that outcome improvements may extend beyond pharmacology alone.
Key takeaway for clinicians: considering collaborative care models that include psychological support could illuminate how patients experience rapid symptom change and may influence the design of multidisciplinary treatment plans for depression.
Article Title: STAT+: Can a psychedelic ‘coach’ make ketamine therapy even more effective?
Link to STAT NEWS Mental Health Article: https://www.statnews.com/2026/04/01/ketamine-therapy-psychedlic-coach-increase-effectiveness-depression/?utm_campaign=rss
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#ketamine #psychedelicassistedtherapy #depressiontreatment #psychotherapyintegration #mentalhealthcare
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253694 #consciousness #ketamine #meditation #psychedelics
The Minimal Phenomenal Experience questionnaire (MPE-92M): Towards a phenomenological profile of “pure awareness” experiences in meditators
Objective To develop a fine-grained phenomenological analysis of “pure awareness” experiences in meditators. Methods An online survey in five language versions (German, English, French, Spanish, Italian) collected data from January to March 2020. A total of 92 questionnaire items on a visual analogue scale were submitted to exploratory and confirmatory factor analysis. Results Out of 3627 submitted responses, 1403 were usable. Participants had a median age of 52 years (range: 17–88) and were evenly split between men and women (48.5% vs 50.0%). The majority of meditators practiced regularly (77.3%), were free of diagnosed mental disorders (92.4%) and did not regularly use any psychoactive substances (84.0%). Vipassana (43.9%) followed by Zen (34.9%) were the most frequently practiced meditation techniques. German (63.4%) and English (31.4%) were by far the most frequent questionnaire languages. A solution with 12 factors explaining 44% of the total variance was deemed optimal under joint conceptual and statistical considerations. The factors were named “Time, Effort and Desire,” “Peace, Bliss and Silence,” “Self-Knowledge, Autonomous Cognizance and Insight,” “Wakeful Presence,” “Pure Awareness in Dream and Sleep,” “Luminosity,” “Thoughts and Feelings,” “Emptiness and Non-egoic Self-awareness,” “Sensory Perception in Body and Space,” “Touching World and Self,” “Mental Agency,” and “Witness Consciousness.” This factor structure fit the data moderately well. Conclusions We have previously posited a phenomenological prototype for the experience of “pure awareness” as it occurs in the context of meditation practice. Here we offer a tentative 12-factor model to describe its phenomenal character in a fine-grained way. The current findings are in line with an earlier study extracting semantic constraints for a working definition of minimal phenomenal experience.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9834329/ #ketamine #psychedelics #ketaminetherapy #psychedelictherapy A unified model of ketamine’s dissociative and psychedelic properties (Marguilho, et al, 2022) #harmreduction #mentalhealth
