Interesting contrast between the editor’s emphasis on Treg involvement in CD8 T cell priming and the complete absence of this point in the authors’ abstract.

#immunology
#IL2
#cytokine
#Tregs

https://www.science.org/doi/10.1126/science.adq1405

“Toisessa maailmansodassa alasammuttu venäläiskone laskeutuu järven pohjasta Smithsonianin museoon.”

“IL-2-kone löydettiin ja kunnostettiin historiallista ensiesiintymistään varten.”

#Ilmailu #Lentokone #Restaurointi #Historia #Il2 #WW2

https://www.washingtonpost.com/history/2024/08/03/russian-plane-world-war-ii-smithsonian/

Okay I bought some cheap pedals to play DCS, Star CItizen and IL-2.

After testing them for 2-3 hours I don't know how I could ever play without them. After the initial learning phase you get so much more control and it feels a lot more immersive.

But yeah the internet is right, pedals is the last piece of hardware you should buy. First of all get a stick and throttle, followed by a headtracker.

If this is done take a look at pedals.

#DCS #StarCitizen #IL2 #Simulator #PCGame #FlightPedals

Hey Fedifriends. I recently jumped back into flight simulation and am looking to make friends with others in the hobby to learn with ​ I fly a mix of DCS, IL2 Sturmovik, and MSFS2020 (also listed in order of hours I've accrued on each), and usually on evenings US West Coast Pacific timezone after work / and on weekends. If we share a platform and a timezone I'd love to hear from you 👋​ See you in the internet skies

#flightsim #dcs #msfs2020 #il2 #FlightSimulator2020 #flightsimulation #DigitalCombatSimulator

(re-toots / signal boosting appreciated)

Molecular and cognitive signatures of #ageing partially restored through synthetic delivery of #IL2 to the brain

By M.G. Holt, L. Yshii, A. Liston & colleagues at VIB-KU Leuven Center for Brain & Disease Research

👉 https://doi.org/10.15252/emmm.202216805

Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.

https://doi.org/10.1016/j.celrep.2022.111937

Key Takeaways:

-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.

-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.

-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.

-Human ILC1 make #il2 but functional relevance of this still unknown.

'As of yet, none of the improved IL-2-based compounds gained regulatory approval for the treatment of cancer or autoimmune diseases. Three compounds treating cancer have entered phase 3 trials with two studies still ongoing. NKTR-214 is the only compound that has completed phase 3 studies.'

#Immunology #Immunotherapy #IL2 #Preprint

https://www.medrxiv.org/content/10.1101/2022.12.02.22283042v1

"A close examination of the IL-2–IL-2Rα binding interface reveals a putative “pH Switch” consisting of the interaction between Arg38 in IL-2 and His120 in IL-2Rα (Fig. 2F). We hypothesized that, at the low pH in the TME, His120 would become protonated, resulting in release of IL-2 from IL-2Rα and therefore lack of signaling."

#Immunology #Cytokine #Immunotherapy #IL2

https://www.science.org/doi/10.1126/sciimmunol.ade5686