Giuseppe Michieli#Cytokine Regulation of #Human #Antibody Responses to #Influenza #Vaccines, https://etidiohnew.blogspot.com/2025/08/cytokine-regulation-of-human-antibody.html
PLOS BiologyReports of diverse stoichiometries have complicated our understanding of the complex between ALK kinase and its #cytokine ligand ALKAL2. @janfelix &co reanalyze #cryoEM data to clarify the situation @PLOSBiology https://plos.io/4lvRfvu
Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries
The mechanistic understanding of the complex between ALK kinase and its cytokine ligand ALKAL2 has been complicated by reports of diverse stoichiometries (2:1 vs 2:2). This study reanalyzes cryo-EM data originally interpreted as showing a 2:2 ALK-ALKAL2 complex, revealing that the dataset includes a population with a novel 2:1 stoichiometry.
David UsharauliInteresting contrast between the editor’s emphasis on Treg involvement in CD8 T cell priming and the complete absence of this point in the authors’ abstract.
The Novel #H10N3 Avian #Influenza Virus Triggers Lethal #Cytokine #Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian #Lungs, https://etidiohnew.blogspot.com/2025/03/the-novel-h10n3-avian-influenza-virus.html
NIOO-KNAWNew publication: Microbial surveillance versus #cytokine responsiveness in native and non-native #housesparrows.
#inflammation #microbialsurvaillance #introducedspecies
https://doi.org/10.1098/rsbl.2024.0431
#inflammation #microbialsurvaillance #introducedspecies
https://doi.org/10.1098/rsbl.2024.0431
Modulation of #cytokeratin and #cytokine/chemokine expression following #influenza virus infection of differentiated #human #tonsillar epithelial cells, https://etidiohnew.blogspot.com/2025/01/modulation-of-cytokeratin-and.html
Blocking cytokine signaling can be an effective therapy for a range of different diseases. @m_elgamacy &co use computational protein design to develop novel #cytokine receptor antagonists, showing G-CSFR inhibition in a cell model of AML #PLOSBiology https://plos.io/41ePP0G
A strategy to design protein-based antagonists against type I cytokine receptors
Protein-based therapies have been developed to block cytokine signaling in a range of different diseases. These authors use a computational protein design approach to develop novel cytokine receptor antagonists and show that the designed proteins can inhibit G-CSFR activation in a cell model of acute myeloid leukemia.
#Age-dependent #Powassan virus #lethality is linked to glial cell activation & divergent neuroinflammatory #cytokine #responses in a murine model, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00560-24?af=R
These findings correlate age-dependent #CNS cytokine responses & viral loads with POWV lethality & suggest potential neuroinflammatory therapeutic targets. Our results establish the age-dependent lethality of POWV in a murine #model that mirrors human POWV severity and long-term CNS pathology in the elderly.
micrordtUnraveling the Significance of CD4: A Key Marker in Immunology
#CDMarker, #CD4, #CD4Marker, #Cytokine, #CytokineProduction, #HelperCell, #ImmuneCell, #Immunity, #TCell #Immunology In the intricate landscape of immunology, CD4 stands out as a fundamental marker, pivotal in orchestrating the body’s defense mechanisms…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -
Nonia ParienteIt's #phage week
@PLOSBiology!
First up, Ellinor Alseth, Edze Westra and colleagues describe the impact of phage & phage resistance on microbial community dynamics
https://plos.io/49OSE9i
Then Jennifer Bomberger and colleagues show that #lytic phages induce #cytokine release from human respiratory epithelium in a cool cross-kingdom interaction
https://plos.io/44dOUgu
♥️♥️
The impact of phage and phage resistance on microbial community dynamics
Phages shape the microbial world. This study uses an evolution experiment to explore how phage impact the structure and dynamics of a four-species bacterial community, finding that phage enables competitive release of the strongest competitor, helps maintain community diversity and prevents reinvasion of the target species.