Mastodawn

Irish Independent : Independent | LinkedIn planning to cut 5pc of staff as tech industry layoffs continue

AI generated summary, Read the full article for complete information.

LinkedIn, the Microsoft‑owned professional networking site that employs over 2,000 people in Ireland, is preparing to cut roughly 5 % of its Irish staff as part of a re‑organisation aimed at focusing resources on faster‑growing business areas, according to Reuters. The layoffs are not linked to AI‑driven job displacement, and come despite a 12 % revenue increase in the latest quarter. The move follows a wave of tech‑sector cutbacks across companies such as Coinbase, Meta, Amazon and PayPal, and follows LinkedIn’s recent opening of a new EMEA headquarters in Dublin and Microsoft’s broader voluntary redundancy programmes in its Irish operations.

#LinkedIn #Microsoft #Coinbase #Meta #Amazon #Oracle #Covalent #PayPal #ActivisionBlizzard #

LinkedIn planning to cut 5pc of staff as tech industry layoffs continue

LinkedIn, which employs over 2,000 people in Ireland, is reportedly preparing staff cuts of around 5pc.

Irish Independent

Stephan Hacker Apr 23

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib. www.linkedin.com/posts/stan-v... #Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

Part 27, drug discovery on an ...

Part 27, drug discovery on an “Undruggable” Target. K‑Ras is a small intracellular GTPase that functions as a molecular switch, activating mitogenic signaling pathways in response to growth… | Stan Van Boeckel

Part 27, drug discovery on an “Undruggable” Target. K‑Ras is a small intracellular GTPase that functions as a molecular switch, activating mitogenic signaling pathways in response to growth factors. Direct attempts to inhibit this oncogene with competitive drugs at its GTP‑binding site failed because of its picomolar affinity for GTP and the high intracellular GTP concentration. Mutations in the K‑Ras pathway, such as K‑RasG12C, render the protein constitutively active, driving uncontrolled proliferation and e.g. contributing to ~40% of K‑Ras–driven lung cancers. Until 2013, K‑Ras was considered non‑druggable, but this view shifted when the Shokat lab revealed a hidden allosteric regulatory pocket in K‑RasG12C that becomes accessible when small electrophilic molecules covalently bind the mutant cysteine. This covalent engagement displaces key “protein switches,” biases the protein toward GDP over GTP conformation and prevents Raf binding, thereby shutting down MAPK signaling. Following this breakthrough, Amgen optimized the Shokat group’s early acrylamide fragments into an in‑vivo‑suitable tool compound, ARS‑1620. Extensive crystallography and docking guided the medicinal chemistry cycles that ultimately produced the highly decorated drug sotorasib (approved in 2021). In phase 3 trials in K‑RasG12C‑mutant lung cancer, sotorasib improved progression‑free survival compared with docetaxel, although overall survival was unchanged. That outcome is somewhat disappointing, but there is hope that real‑world drug combination strategies may yet deliver meaningful gains in overall survival.

Stephan Hacker Apr 23

Another interesting #SciComm post by Stan Van Boeckel! K-Ras #DrugDiscovery from being considered #Undruggable to the clinical approval of the #covalent #inhibitor Sotorasib.

https://www.linkedin.com/posts/stan-van-boeckel-a0089b15_part-27-drug-discovery-on-an-undruggable-activity-7452806289342164992-ii04?utm_source=share&utm_medium=member_desktop&rcm=ACoAACVzmDsB7J_8sWXEOBYlnnAs1T4cVcDlrxQ

#Science #ScienceCommunication #Medicines #StoryTelling #Cancer #KRAS #CovalentInhibitor

Part 27, drug discovery on an “Undruggable” Target. K‑Ras is a small intracellular GTPase that functions as a molecular switch, activating mitogenic signaling pathways in response to growth… | Stan Van Boeckel

Part 27, drug discovery on an “Undruggable” Target. K‑Ras is a small intracellular GTPase that functions as a molecular switch, activating mitogenic signaling pathways in response to growth factors. Direct attempts to inhibit this oncogene with competitive drugs at its GTP‑binding site failed because of its picomolar affinity for GTP and the high intracellular GTP concentration. Mutations in the K‑Ras pathway, such as K‑RasG12C, render the protein constitutively active, driving uncontrolled proliferation and e.g. contributing to ~40% of K‑Ras–driven lung cancers. Until 2013, K‑Ras was considered non‑druggable, but this view shifted when the Shokat lab revealed a hidden allosteric regulatory pocket in K‑RasG12C that becomes accessible when small electrophilic molecules covalently bind the mutant cysteine. This covalent engagement displaces key “protein switches,” biases the protein toward GDP over GTP conformation and prevents Raf binding, thereby shutting down MAPK signaling. Following this breakthrough, Amgen optimized the Shokat group’s early acrylamide fragments into an in‑vivo‑suitable tool compound, ARS‑1620. Extensive crystallography and docking guided the medicinal chemistry cycles that ultimately produced the highly decorated drug sotorasib (approved in 2021). In phase 3 trials in K‑RasG12C‑mutant lung cancer, sotorasib improved progression‑free survival compared with docetaxel, although overall survival was unchanged. That outcome is somewhat disappointing, but there is hope that real‑world drug combination strategies may yet deliver meaningful gains in overall survival.

Stephan Hacker Mar 13

Great talk by Phillip Yesley from the group of Wim Velema at #Lunteren2026.

He discussed the use of mutational profiling to find covalent ligands for structured #RNA using acyl imidazoles as the reactive group.

https://onlinelibrary.wiley.com/doi/10.1002/ange.202517243
#Chemistry #ChemBio #Covalent #CovalentInhibitor

Stephan Hacker Mar 13

Great talk by Phillip Yesley from the group of Wim Velema at #Lunteren2026. He discussed the use of mutational profiling to find covalent ligands for structured #RNA using acyl imidazoles as the reactive group. onlinelibrary.wiley.com/doi/10.1002/... #ChemSky #ChemBio #Covalent #CovalentInhibitor

Stephan Hacker Nov 24

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once. #ChemSky #ChemBio #DrugDiscovery

Stephan Hacker Nov 24

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#Chemistry #ChemBio #DrugDiscovery

Stephan Hacker Aug 12, 2025

Very excited that our group was awarded an NWO XS grant to support our research into new #covalent #antibiotics for Gram-negative bacteria!

Thank you to Storm van der Voort for help with finalizing the proposal.

Congratulations also to all other recipients of the grant!

https://www.nwo.nl/en/news/48-grants-for-the-open-competition-domain-science-xs
#ChemSky #ChemBio

48 grants for the Open Competition Domain Science- XS | NWO

48 projects will receive 2.4 million euros from the Open Competition Domain Science- XS round 25-2. The subjects vary from identification of the most effective fungal cutinase for plastic recycling to comparing gene expression and cellular behaviour of these scar-forming cells with cells from pulmonary emboli that do not show scars.

NWO

Stephan Hacker Aug 12, 2025

Excited that our group was awarded an NWO XS grant to support our research into new #covalent #antibiotics for Gram-negative bacteria! Thank you to Storm van der Voort for help with the proposal. Congratulations also to all other recipients of the grant! www.nwo.nl/en/news/48-g... #ChemSky #ChemBio

48 grants for the Open Competi...

48 grants for the Open Competition Domain Science- XS | NWO

48 projects will receive 2.4 million euros from the Open Competition Domain Science- XS round 25-2. The subjects vary from identification of the most effective fungal cutinase for plastic recycling to comparing gene expression and cellular behaviour of these scar-forming cells with cells from pulmonary emboli that do not show scars.

NWO

Habr Aug 6, 2025

Планировщики процессов для необычных областей знаний

Продолжаем обсуждать примечательные инструменты для автоматизации и управления рабочими процессами (и напоминаем про

https://habr.com/ru/companies/mws/articles/919126/

#workflow #работа_с_данными #Covalent #Cromwell #Cylc #Martian #MWS #MWS_Tables

Планировщики процессов для необычных областей знаний

Продолжаем обсуждать примечательные инструменты для автоматизации и управления рабочими процессами (и напоминаем про MWS Tables — платформу для командной работы, включающую таблицы, трекер задач,...

Хабр