Stephan HackerNov 26
I hope I could convey some of the great science that was presented in >50 talks at the 3rd International Symposium on Chemical Proteomics and Drug Discovery in Guangzhou. If you want to read my summaries, check out #ISCPDD. Thank you so much again to Zhengqiu Li for organizing and inviting me.
Stephan HackerNov 26

I hope I could convey some of the great science that was presented in >50 talks at the 3rd International Symposium on Chemical Proteomics and Drug Discovery in Guangzhou.

If you want to read my summaries, check out #ISCPDD.

Thank you so much again to Zhengqiu Li for organizing and inviting me.

#Chemistry #ChemBio #DrugDiscovery #Chemoproteomics #ChemPro #ProteoProbes

Stephan HackerNov 26
Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells. pubs.rsc.org/en/cont... #ABPP #AfBPP #ChemSky #ChemBio #ProteoProbes #ChemPro

Chemical proteomic profiling r...
Stephan HackerNov 26

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

https://pubs.rsc.org/en/content/articlelanding/2025/cc/d4cc05681g
#ABPP #AfBPP #Chemistry #ChemBio #ProteoProbes #ChemPro

Stephan HackerNov 25
Great presentation by Billy Ng at #ISCPDD. He talked about the use of induced proximity to study protein O-GlcNAcylation. Exciting work on recruiters that bring together OGT and a target protein. pubs.acs.org/doi/ful... #ChemSky #ChemBio #Glycotime

Targeted Protein O-GlcNAcylati...
Stephan HackerNov 25
Great presentation by Billy Ng at #ISCPDD. He talked about the use of induced proximity to study protein O-GlcNAcylation. Exciting work on recruiters that bring together OGT and a target protein.
https://pubs.acs.org/doi/full/10.1021/jacs.3c14380
#Chemistry #ChemBio #Glycotime
Stephan HackerNov 25
Great talk by Nathanael Gray at #ISCPDD. He presented his group’s work on induced proximity to regulate transcription. Exciting data on recruiting a transcriptional activator (e.g. BRD4 or CDK9) to replace co-repressors on the death regulator BCL6 to induce cell death.

Rewiring cancer drivers to act...
Rewiring cancer drivers to activate apoptosis - Nature

A new class of molecules can recruit downstream transcription factors or endogenous cancer drivers to cell death promoters and activate the expression of these genes.

Nature
Stephan HackerNov 25

Great talk by Nathanael Gray at #ISCPDD. He presented his group’s work on induced proximity to regulate transcription. Exciting data on recruiting a transcriptional activator (e.g. BRD4 or CDK9) to replace co-repressors on the death regulator BCL6 to induce cell death.

https://www.nature.com/articles/s41586-023-06348-2
#Chemistry #ChemBio #InducedProximity

Rewiring cancer drivers to activate apoptosis - Nature

A new class of molecules can recruit downstream transcription factors or endogenous cancer drivers to cell death promoters and activate the expression of these genes.

Nature
Stephan HackerNov 25
Great talk by Xinyuan Fan at #ISCPDD. He talked about his group’s exciting work on using #photocatalysis to profile the proteins and the RNA in specific compartments in the cell on the example of mitochondria, Golgi, ER and lysosome. doi.org/10.1038/s415... #ChemBio #ChemSky #ProximityLabeling

Photocatalytic labelling-enabl...
Stephan HackerNov 25
Great talk by Xinyuan Fan at #ISCPDD. He talked about his group’s exciting work on using #photocatalysis to profile the proteins and the RNA in specific compartments in the cell on the example of mitochondria, Golgi, ER and lysosome.
https://doi.org/10.1038/s41557-025-01946-1
#ChemBio #Chemistry #ProximityLabeling