The EMBO JournalAug 9, 2023
Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510
The EMBO JournalJul 5, 2023
Centrosome linker diversity: #Ninein, #Rootletin & #CNap1 contribute specific functions to #centrosome clustering and spindle formation, some of which matter in cells with extra #centrosomes
Laura Theile, Xue Li, Elmar Schiebel et al #UniHeidelberg
https://www.embopress.org/doi/full/10.15252/embj.2021109738
Priti S AtmakuruMay 5, 2023

Spindle in dividing cells,
single when it sleeps.
Bids goodbye in fusing cells,
so many secrets to reveal!
Our Opinion on the cilium-centrosome axis buzzing with activity during fate choice! Now @J_Cell_Sci

#cilia #centrosomes #centriolarsatellites #RNA

https://journals.biologists.com/jcs/article-abstract/136/9/jcs260454/308872/The-cilium-centrosome-axis-in-coupling-cell-cycle?redirectedFrom=fulltext

cilium–centrosome axis in coupling cell cycle exit and cell fate

Summary: The cilium–centrosome complex regulates cell polarity and cell division, but does it help cells decide their fate? We discuss how this complex can influence cells to proliferate, enter quiescence or differentiate.

The Company of Biologists
Mill_labNov 23, 2022
Welcome to the #Fediverse @BazziLab  ! Glad you are here! #Cilia #Centrioles #Centrosomes #DevBiol #Mouse
Tim StearnsNov 9, 2022

We know that #centrosomes are not required for mitotic division, so what are they good for?

New preprint from grad student KC Farrell shows that having two duplicated centrosomes at the beginning of #mitosis facilitates rapid bipolar spindle formation. In the absence of centrosomes there is a checkpoint-mediated delay that is required to give enough time to sort things out and assemble the spindle.

#CellBiology
https://www.biorxiv.org/content/10.1101/2022.11.08.515699v1.full.pdf

Tim StearnsNov 6, 2022

#introduction
Hello #ScienceMastodon community!

I am a professor at Rockefeller University in #NYC and dean of the graduate school. Interested in all things #science, but especially #CellBiology, #centrosomes, #cilia, #CellCycle, the #cytoskeleton and #microscopy.

I also want to make science a better place for students and postdocs, and am interested in science education, outreach, publishing and policy. #ScienceEducation

Occasional infrared and film #photography posts to keep it interesting