NoodlemazNov 21

I hope everyone's watching #CancerDetectives on Channel 4!
My team has sweated over various aspects of this. It's a big passion project, my colleague's second baby, and hopefully will help more people understand what it means to do #CancerResearch today, and indeed what it means to have cancer now, compared to some decades ago.

#channel4 #cancer #cancerVaccines #BrainTumours #LiquidBiopsy #cancerOfUnknownPrimary #LungCancer #P53 #liFraumeni #5GTrial #MILITrial #DETECTION2Trial #CancerResearchUK

Show threadmillerebondsNov 7

@aral @Rawan_kh22 @alaa123 @salemgaza @Hackingsocial @RichardMonvoisin @defakator

For me there is a striking resemblance between humans trying to do social manipulation and p53 protein theme.

Like carcinogenic viruses, perversion, indoctrination and other problems, people who do power abuses need to fight against safeguards

P53 is often one of the first safeguard with harmful mutation in cancers..

#hackingsocial #biology #technofascism #technofeudalism #checksandbalances #p53 #carcinogenesis

FranckRaischJun 8
#TP53 ist ein Gen, welches #Krebs bekämpft: es eliminiert kranke Zellen, bevor diese Krebs entwickeln. Wir Menschen haben wie fast alle Säugetiere eine Kopie dieses #P53 Gens, welches Tumore verhindert und DNA repariert. Afrikanische Elefanten haben 20 von diesen Tumorkillern. Folglich sind sie bestens vor Krebs geschützt https://pmc.ncbi.nlm.nih.gov/articles/PMC5061548/
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. ...

PubMed Central (PMC)
Chayan MunshiJun 3

New Publication Alert!
"The Effective Stress Response Role of p53 in Inducing Ferroptotic Cell Death"


Link:
https://lnkd.in/gPA6qVdC


#p53 #ferroptosis #stress #celldeath

Hacker NewsMay 21

Elephants evolved to beat cancer, and how we could too

https://newatlas.com/biology/elephants-beat-evolution-cancer-p53-gene-petos-paradox/

#HackerNews #Elephants #Cancer #Evolution #P53 #Gene #Petos #Paradox

How elephants evolved to beat cancer, and how we could too

Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically experience unusually low rates of cancer. The research found these remarkable mammals carry unique genetic variants that reduce their risk of tumors, and the findings could…

New Atlas
The Conversation U.S.Feb 25
The protein #p53, known as the "guardian of the genome," plays a crucial role in preventing #cancer. When it malfunctions, tumors can form. Scientists are developing drugs to restore or mimic p53's function in cancer cells. A #biology researcher explains:
https://theconversation.com/p53-is-both-your-genomes-guardian-and-weakness-against-cancer-scientists-are-trying-to-repair-or-replace-it-when-it-goes-awry-248674 #science
p53 is both your genome’s guardian and weakness against cancer – scientists are trying to repair or replace it when it goes awry

The gene that codes for p53 is the most frequently mutated in cancer. Researchers are targeting different parts of its complex pathway to restore its ability to stop cancer.

The Conversation
millerebondsFeb 15

Vous avez vu passer ça ?

https://xcancel.com/elonmusk/status/1890612949368058118#m

Il utilise le terme !

C'est exactement ce que sont tous les tarés autour de Trump: des virus cancérigènes, qui font sauter tous les garde-fous jusqu'à la réalité elle-même pour proliférer

#trump #musk #virus #maga #mega #usa #postverite #complotisme #bullshit #manipulation #psychologie #sociologie #croyances #espritcritique #intelligence #factchecking #p53 #cancer #racisme #antifa #antifascisme #harcelement #perversion #etatsunis #fascisme

xyhhx 🔻Dec 9, 2024

my qubes laptop has about as many vms defined as my kubernetes cluster has pods. my thinkpad has as much or more memory than all of my servers

#qubesOS #qubes #kubernetes #k8s #thinkpad #p53

Matt WillemsenMar 8, 2024
Company that plans to bring back the mammoth takes a key step
https://arstechnica.com/science/2024/03/de-extinction-company-manages-to-generate-first-elephant-stem-cells/ #rewilding #deextinction #mammoth #Colossal #mastodon?🦣 #manuscript #elephant #genome #p53
Company that plans to bring back the mammoth takes a key step

Making elephant stem cells required an elaborate process, lots of failures.

Ars Technica
The EMBO JournalAug 9, 2023
Extra #centrosomes are initially anti-#tumorigenic but why?
Irmina Garcia-Carpio, Andreas Villunger et al find that through #PIDDosome activation, they not only induce #p53 responses, but also #NFkB signaling to increase #immunogenicity of cancer cells
https://www.embopress.org/doi/full/10.15252/embj.2023113510