Neighborhood dispute among cells: whichever successfully exerts force wins

Trial of strength at the cellular level: cells are in constant competition with each other and so eliminate diseased or unwanted cells. Cell competition is therefore a central principle for maintaining the health of tissues and organs. Researchers have investigated the success factors of superior cells and discovered a previously unknown winning strategy in mechanical cell competition. They identified a variety in the ability of cells to exert mechanical forces onto other cells as the decisive regulator. With their results recently published in ‘Nature Materials,’ the research team from Germany, France and Denmark challenges the classical interpretation of cell competition.

Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

Disease Models & Mechanisms

Read Volume 15 Issue 11 of Disease Models & Mechanisms.

Reducing the aneuploid cell burden – cell competition and the ribosome connection

Summary: We review evidence that aneuploid cells are eliminated in the presence of normal cells and the potential role of ribosomal protein gene haploinsufficiency in this cell competition process.

Cell competition may explain cancer relapses, research suggests

A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free, a new study by UT Southwestern researchers suggests.