"deletion of..Mitofusin2 (MFN2), which serves as a tether for MAM, in human induced pluripotent stem (iPS) cells or the reduction of MAM in differentiated #myotubes caused by microgravity..increased susceptibility to #muscle #atrophy, as well as the activation of..Notch..The atrophic phenotype..in microgravity & the regenerative capacity of Mfn2-deficient muscle stem cells in dystrophic mice were both ameliorated by treatment with the gamma-secretase inhibitor DAPT"

https://elifesciences.org/articles/89381

Check out our latest complete issue that includes heaps of #OpenAccess science:

🎇A cover featuring differentiated #myotubes derived from #FSHD patient cells
🧠An Editorial that discusses how we can improve #mouse modelling of #Schizophrenia
🧫A review on aneuploidy & #CellCompetition that explores their impact on #cancer
👂🏼 A review on #InnerEar development & disease
🐹🐭A #COVID19 model stand-off for the #EditorsChoice
🧪And much more fantastic #biomedical research

📘https://journals.biologists.com/dmm/issue/15/11