DMM JournalAneuploidy, the gain or loss of chromosomes, can cause birth defects, miscarriage, #cancer predisposition and age-related disorders.
In a brand new review, Nicholas Baker from Albert Einstein College of Medicine and Cristina Montagna from Rutgers Cancer Institute of New Jersey discuss evidence that #aneuploid cells are eliminated in the presence of normal cells and the potential role of ribosomal protein #gene #haploinsufficiency.
https://journals.biologists.com/dmm/article/15/11/dmm049673/285137/
#OpenAccess #CellCompetition
Reducing the aneuploid cell burden – cell competition and the ribosome connection
Summary: We review evidence that aneuploid cells are eliminated in the presence of normal cells and the potential role of ribosomal protein gene haploinsufficiency in this cell competition process.