AutisticMumTo3Sep 25, 2024

Researchers identify genetic mutations for rare disorder causing cognitive decline
https://medicalxpress.com/news/2024-09-genetic-mutations-rare-disorder-cognitive.html

#Neuroscience
#CognativeDecline
#Genetics
#CSF1R
#Mutations

Researchers identify genetic mutations for rare disorder causing cognitive decline

A rare cause of hereditary cognitive decline known as CSF1R-Related Disorder (CSF1R-RD) gets its name from mutations in the CSF1R gene, discovered by Mayo Clinic. Memory loss occurs as the condition advances, while early symptoms include personality changes, anxiety, depression and loss of inhibition. Genetic testing has become more widely available, but there is no cure for the disorder.

Medical Xpress
Victoria Stuart 🇨🇦 🏳️‍⚧️Jul 26, 2024

New drug shows promise in clearing HIV from brain
https://www.sciencedaily.com/releases/2024/07/240725193914.htm

* experimental drug orig. developed to treat cancer may help clear HIV f. infected cells in brain
* drug may clear virus f. hidden areas that have been a major challenge in HIV treatment

CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae153/7714669

#HIV #SIV #chemotherapy #AIDS #neuroscience #ImmuneSystem #CSF1R #BLZ945 #PerivascularMacrophage #macrophages

New drug shows promise in clearing HIV from brain

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

ScienceDaily
Fabrizio MusacchioSep 11, 2023

Lindsay Hohsfield will talk about "Using #CSF1R #inhibitors to uncover #myeloid cell trafficking routes into the #CNS"

⏰ September 11th, 2023, 12 pm
📍 @dzne

#Neuroscience

Scientific FrontlineJun 29, 2022
The researchers found that the drug — known as a colony-stimulating factor 1 receptor (#CSF1R) inhibitor — helped slow the progress of Duchenne muscular dystrophy in mice by increasing the resiliency of muscle fibers.
#DMD #MuscularDystrophy #Biology #Medical #sflorg
https://www.sflorg.com/2022/06/bio06292202.html
Cancer drug shows potential as treatment for muscular dystrophy

Duchenne muscular dystrophy (DMD) is a severe genetic disorder that leads to progressive muscle weakness.