🧠 New paper from the @MaFu55 lab! 🥳

Felix shows that #microglia shape #glioblastoma invasion at the far infiltration zone. Using in vivo #3photon #imaging, he finds dynamic microglial responses, and shows that microglial manipulation reduces GB migration and limits #tumormicrotube #plasticity.

📝 https://doi.org/10.1016/j.immuni.2026.03.010

#Neuroscience 🧪 @dzne #3P

🧠 New publication from our lab 🥳! Nala ( @MaFu55 Lab, @dzne) & Naya (Corentin Le Magueresse Lab) show that #schizophrenia-associated complement C4 impairs #synaptic connectivity and alters #microglia–synapse interactions via #CR3 signaling.

📝 https://doi.org/10.1016/j.celrep.2026.117161

#Neuroscience 🧪 #2pImaging

Researchers Identify How Lecanemab Activates Microglia to Clear Alzheimer’s Plaques

📰 Original title: Scientists finally reveal how this Alzheimer’s drug really works

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/researchers-identify-how-lecanemab-activates-microglia-to-clear-alzheimers-plaques/?redirpost=9083b0ff-1f62-4776-8975-a38260c90d9c

#health #alzheimers #lecanemab #microglia

Reason this briefing matters for mental health professionals: It highlights a mechanistic link between immune activation in the brain and amyloid clearance, which may inform understanding of neuroinflammatory processes involved in cognitive decline and dementia. Awareness of how biological targets influence neural health can illuminate potential avenues for interdisciplinary collaboration and referral strategies when addressing memory-related concerns in clients.

Article Title: Scientists finally reveal how this Alzheimer’s drug really works

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260317064457 dot htm

#alzheimers #immuneactivation #microglia #neurodegeneration #therapeutics

Copy and paste broken link above into your browser and replace "dot" with "." for link to work.

We have to do it this way to avoid display of copyrighted images.

RE: https://fediscience.org/@eLife/116238133569931871

In mice, but very interesting. A commentary on the research paper:

"Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology", Nemec et al. 2026
https://elifesciences.org/articles/102900

#neuroscience #microglia #mice #neuropathology

🧫 Microglia - Feb 2026

• IL-10 variant boosts neurogenesis and cognition in aged mice
• RIPK1 inhibition blocks pro-inflammatory drivers of Alzheimer
• BTK inhibition reduces neuroinflammation in ALS models
• Distinct epigenomic subtypes reveal unique microglial signatures in Alzheimer's
• Microglia-T cell interactions drive neurodegeneration in Huntington's
• TGF-β inhibition in microglia stimulates adult neurogenesis

https://pir.sh/JoZa0Nr1Gy

#Microglia #Neuroinflammation #Neurodegeneration

#cervello #microglia Invecchiamento cerebrale e smaltimento rifiuti

https://www.notizie.buzz/articles/2026/02/28/invecchiamento-cerebrale-e-smaltimento-rifiuti.html

🧠 Alzheimer Microglia — Jan 2026

• Distinct microglial states emerge with disease-specific gene programs
• TREM2 and metabolic wiring shape microglial function in AD
• Environmental and infectious signals modulate neuroinflammation
• Exosomes, miRNAs, and Aβ disaggregation explored as therapeutic angles

https://pir.sh/z0odQxl1LO

#Alzheimers #Microglia #Neuroinflammation #Neuroscience