Mastodawn

Postdoc Fellows (1-2): Decoding Cancer-Host interactions
Academia Sinica, Genomics Research Center

Join us as a #postdoc decoding #pancreaticcancer metabolism & #neuroimmunology at Academia Sinica's elite, English-speaking research hub in Taipei!

See the full job description on jobRxiv: https://jobrxiv.org/job/academia-sinica-genomics-research-center-2...
https://jobrxiv.org/job/academia-sinica-genomics-research-center-27778-postdoc-fellows-1-2-decoding-cancer-host-interactions/?fsp_sid=13006

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Psychotherapy Commission ACPE Jun 15

The article reports that retired combat and collision athletes with extensive blood-brain barrier disruption tend to show greater cognitive decline, linked to higher systemic inflammation and alterations in immune pathways. Repetitive head trauma in contact sports may contribute to long-term brain changes and cognitive difficulties, even after stopping exposure.

These findings hold interest for psychology readers because they illuminate how physical experiences and biological processes intertwine with cognitive aging and emotional well-being, highlighting the mind-brain-body connection in real-world athletic contexts.

Article Title: Head injuries in contact sports linked to leaky brain barrier and cognitive decline

Link to PsyPost Article: https://nolinkpreview.com/www.psypost.org/head-injuries-in-contact-sports-linked-to-leaky-brain-barrier-and-cognitive-decline/

#headinjuries
#bloodbrainbarrier
#cognitivedecline
#repetitiveheadtrauma
#contactsports
#inflammation
#neuroimmunology
#traumaticencephalopathy
#neuroscience
#athletichealth

Scientific Frontline Jun 14

Traumatic brain injuries (TBI) activate the brain's innate immune system—specifically toll-like receptor 4 (TLR4)—which subsequently elevates the enzyme MMP-9 to disrupt neuronal communication, leading to memory loss, seizures, and impaired cognition.
#Neuroscience #Neuroimmunology #MolecularBiology #Pharmacology #sflorg
https://www.sflorg.com/2026/06/ns06142601.html

Immune Signaling in Brain Injuries

Discover how the TLR4-MMP-9 immune pathway worsens concussions and how early targeted inhibition could prevent lifelong neurological deterioration.

Fabrizio Musacchio Jun 9

🧠🚓 New paper on #microglia depletion: #CSF1R inhibition with #PLX5622 is not microglia-specific, it also depletes long-lived peripheral #macrophage populations. Could become important for interpreting #microglial #depletion experiments: Phenotypes after depletion or recovery may reflect broader macrophage niche perturbation, not microglia alone:

📄 https://doi.org/10.1016/j.celrep.2026.117411

#Neuroscience #Neuroimmunology

Scientific Frontline Jun 4

Irisin is a muscle-derived hormone released during aerobic exercise that directly shields neurons from damage and reduces clinical disability in preclinical models of multiple sclerosis (#MS ).
#Neurology #Neuroimmunology #Neuroendocrinology #MolecularBiology #sflorg
https://www.sflorg.com/2026/06/ns06042603.html

Irisin Hormone: A Neuroprotective Target for MS

The exercise hormone irisin directly shields neurons from damage in multiple sclerosis, offering a novel pathway for progressive therapies.

Fabrizio Musacchio May 22

🧠📐 Kaltenecker et al present #MouseMapper, that combines whole-body tissue clearing, #lightsheet #imaging and foundation-model-based #DeepLearning to quantify nerves, immune cells & 31 organs/tissues across entire #mouse bodies.

Applied to diet-induced #obesity, it revealed reduced nerve density, infraorbital trigeminal nerve defects, impaired whisker sensing, & body-wide inflammatory CD68⁺ immune-cell clustering.

🌍 https://doi.org/10.1038/s41586-026-10535-2

#Neuroscience #Neuroimmunology #BioimageAnalysis #AI

Fabrizio Musacchio May 20

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

Scientific Frontline May 1

Severe #narcolepsy with cataplexy is caused by the degeneration of neurons in two distinct regions of the brain: the hypothalamus and the locus coeruleus. This dual-region damage disrupts the production of both hypocretin and norepinephrine, which are critical chemical messengers for regulating wakefulness and muscle tone.
#Neuroscience #Neurology #Neuroimmunology #Psychiatry #sflorg
https://www.sflorg.com/2026/05/ns05012601.html

Severe narcolepsy found to damage a second brain region

UCLA researchers discovered that severe narcolepsy damages a second brain region, the locus coeruleus, opening doors for new targeted therapies.

Psychotherapy Commission ACPE Feb 25

This brief highlights a mechanistic target in an autoimmune brain disorder, offering a concise point of relevance for clinicians focused on neuropsychiatric presentations. Understanding the NMDA receptor-centered pathophysiology informs caseload awareness where psychiatric symptoms intersect with neuroimmune processes, aiding differential thinking and collaboration with neuroscience colleagues.

Article Title: New drug target discovered for devastating “brain on fire” disease

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/02/260225081150 dot htm

#brainhealth #neuroimmunology #NMDAreceptors #neuropsychiatry #autoinflammatorydisease

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