Mastodawn

@avilewis Any politician who truly cares about wellbeing of all citizens, not just the lives of privileged people, would spearhead much better, preventative public health policies. A sustainable workforce, requires a strong rather healthy population. How every political party/politician here has normalized getting infected with covid multiple times - when that's preventable - is not true leadership. Long covid disabilities have hampered a lot of prior workforce & is continuing to strip more people from workforce. Not a single political party has any idea on how to deal with increasing funds needed to help newly disabled folks - who are unable to keep working with their long covid issues & with other medical issues triggered by covid infections like TB, Lyme disease, neurological dysfunctions & multiple organs damages - to name but a few that has been directly attributed to covid infections.

Will you wait until you or someone you deeply love to die or become disabled from covid, before you step up to lead by example? You'd be the first & millions of us would support you with leading better, by living example & demonstrating your words are not empty but you actually do care about disabled folks & every citizen, even most of you who normalized covid - when it should've never been normalized.

#CDNpoli #FailureToProtect #CovidNeverEnded #CovidStillKills #LongCovidHealthCrisis #NDP #DisabledLivesMatter #CovidIsNotOver #CovidSafety #UnmaskedPlagueSpreaders #DoBetter #StopEugenics #Disability #Covid #LeadByBetterExample #BCpoli #Canada #PeopleWithDisabilities #Autoimmune #HealthCare

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not nice but a person 2d ago

my #Metapsychotic pet theory: it's not entirely useless to view #Psychosis as an #Autoimmune condition of the #Cognitome. 🫤❓

see, I can repeatedly commit the awful #fauxpas of inventing #jargon all by myself, without assistance from a particular #discipline, nor from the generalized #LargeLanguageMachine! 😁

already by itself a sufficient reason to be #tunedout of the #vibe, I know I know

the worst part?

you can do this, too!

🧶

Daniel Hoffmann 🌼3d ago

Somatic mutations are not only a crucial factor in cancer but can also be critical for #thyroid #autoimmune disease

https://www.nature.com/articles/s41586-026-10493-9

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity - Nature

Our immune system contains multiple checkpoints to prevent the activation of self-reactive lymphocytes. How some lymphocytes escape these constraints to cause autoimmune disease remains poorly understood. A long-standing hypothesis posits that somatic mutations in immune-regulatory genes may enable self-reactive lymphocytes to bypass tolerance checkpoints1–3, but testing this has been challenging due to technical limitations. Here, we use whole-exome and targeted NanoSeq4,5, an accurate single-molecule DNA sequencing protocol, to comprehensively search for driver mutations in autoimmune thyroid disease. This revealed many B cell clones convergently acquiring loss-of-function mutations in the key immune checkpoint genes TNFRSF14 (HVEM) and CD274 (PD-L1), as well as less frequent mutations in other immune genes. In highly inflamed biopsies, we detected tens to hundreds of independent immune checkpoint mutant clones. Laser microdissection, methylation sequencing, spatial transcriptomics, immunostaining, single-nucleus DNA sequencing, and antibody synthesis localised these mutations to B cells, confirmed some to be self-reactive, and identified clones carrying multiple hits. We found widespread TNFRSF14 biallelic loss, and clones with as many as 4-6 driver mutations. Whilst each clone accounts for a small fraction of cells (typically <1%), the myriad mutant clones in each donor amounted to a substantial fraction of B cells harbouring driver mutations. Our results support the hypothesis that somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease.

Nature

clown event still possib-L Apr 10

It is drugs day, the day where my immune system is at its strongest and most aggressive, and I went to a museum yesterday.

I feel like GARBAGE. My throat hurts, my back hurts, I'm fairly certain someone has filled my blanket with lead weights, my eyes are drier than the Sahara.

I've been awake for maybe ten minutes. I have to get up to do my injection to make everything better, but that's two rooms away, which is unfathomably far.

#NEISvoid #ChronicIllness #autoimmune

Ken Everett (Ken's Blogspot)Apr 10

#EastHer Grassroots Youth #Football Festival kicks off -
https://kensbookinfo.blogspot.com/p/world-capitals.html#Roseau

In #Medical First, a Single Therapy Knocked Out 3 #Autoimmune -
https://kensbookinfo.blogspot.com/p/etc-varied.html#6

#Charlotte County Fire & EMS crews assist in helicopter -
https://kensbookinfo.blogspot.com/p/politics.html#19

The ageless Queen Letizia of #Spain, 53, recreates her -
https://kensbookinfo.blogspot.com/p/world-capitals.html#Madrid

#Today I learned what a social media bot farm looks -
https://kensbookinfo.blogspot.com/p/infotech.html#100

View all news from Ireland https://kensbookinfo.blogspot.com/2026/03/latest-news-from-ireland.html

World Capitals

The latest news and headlines, featuring real time updates for countries, cities, states, politics, economy, sports, food, culture via Ken's Blogspot

Scientific Frontline Apr 10

Researchers have established that mutations in non-protein-coding genes—specifically those responsible for producing functional #RNA molecules—are a direct cause of #autoimmune neonatal #diabetes in #infants
#Genomics #MolecularBiology #Immunology #Endocrinology #sflorg
https://www.sflorg.com/2026/04/geno04102601.html

New cause for diabetes in babies found in non-coding genes

Scientists have found new genetic causes for diabetes in babies – in a part of the genome that has historically been overlooked in genetic studies

Old Black Cat Apr 7

What is it like to live with extreme hypothyroidism...

I'm trying to stop taking T3 (triiodothyronine - liothyronine), but today, in 20°C weather, I had a rather unpleasant bout of hypothermia. My core temperature (measured at the eardrum) wouldn't go above 35°C, and I had stomach pain and shivering. Autumn is just starting here, and it began with damp and somewhat chilly weather. I don't know if it will be possible for me to stop taking T3 because my thyroid isn't functioning properly, and the conversion of T4 to T3 isn't working well at all. The problem is that a day like this means terrible digestion, extreme fatigue, feeling cold, drowsy, and depressed. I can't concentrate on anything. The main reason I'm trying to stop taking this hormone is primarily the price, and secondly, because it tends to raise my blood sugar and induce hypomanic states (it acts as an antidepressant, which I can't take, because I'm bipolar).

That's my life with autoimmune atrophic thyroiditis (Hashimoto).

#hypothyroidism #hashimoto #autoimmune #autoimmunedisease #diabetes #bipolar #bipolardisorder #thyroid #actuallyautistic #endocrinology #medicine

Bryan (he/him) 🇺🇸 🏳️‍🌈Apr 5

So, my UCTD appears to be in remission or something. My ANA and ESR labs came back. ANA shows negative for the first time since diagnosis, it was 1:320. ESR is down to 12 after peaking at 32. I think what I have been feeling has been residual of my last flare.

#UCTD #AutoImmune #Health #Update