kari hoffman

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167 Posts

Cognitive neurophysiologist. Computational neuroethologist. I lead a lab at Vanderbilt University. We do: Many units. Some fields. No RF mapping. [She/her]

Knowledge enables judicious action, so how exactly do we gain knowledge from experience? What are the neural circuit dynamics that guide learning, and give rise to cognition and adaptive behaviors? What learning rules govern natural and artificial intelligence?

Research topicspopulation geometry, memory replay, sequence learning, concept learning, cell assemblies, oscillations, functional cell types
MethodsHiDensity wireless ephys, closed-loop stim, freely-moving NHP, machine learning
InstituteVanderbilt University
ORCIDhttps://orcid.org/0000-0003-0560-8157

I find this article by Ferro just out in nature communication https://rdcu.be/dOzT2 is an interesting intersection between value-based decision-making, embodied cognition/active vision, and memory #reactivation or #reinstatement. Looking is doing some heavy lifting. And lookie there, I didn't even mention the #orbitofrontalcortex recordings they did!

It caught my eye (sorry) b/c some of the scanpath analysis our lab's done in the past suggests that prior to looking at a remembered, rewarded visual target, there's an uptick in #hippocampal #ripples (Leonard et al., Current Biol 2017), which are thought to signal the underlying reactivation of task-relevant activity patterns. And of course, there's work by a number of groups on memory guidance to rewarding/goal targets, that rely on hippocampal function. Ours based on an MTL amnesic: Yoo, et al., (2020). Long-term memory and hippocampal function support predictive gaze control during goal-directed search. Journal of Vision, https://doi.org/10.1167/jov.20.5.10 following from Chau et al., 2011, and the changes in scanpaths and pupil responses of aging adults and people with Alzheimer's disease, too: Dragan, M. C.,et al., (2017). Behavioural Brain Research, https://doi.org/10.1016/j.bbr.2016.09.014

Where we choose to look says so much: see e.g. Kragel/Voss; Castelhano/Henderson, Wynn/Buchsbaum/Olsen/Ryan esp what Jordana Wynn followed up with on the scanpath reinstatements suggests a really intertwined relationship between memory, eye movements, and learning/decisions about goals. (forgive that I'm missing many others and pls add below!)

TL;DR The foraging decision-making folks and the memory-guided vision folks need to be increasingly up in each other's business.

Here's that Ferro link:
https://rdcu.be/dOzT2

@cogneurophys

@LMPrida @perpl_lab @acnavasolive @saman @cogneurophys 🥳so happy this is out! I wasn’t sure how the ML models would perform, given the frequency shift in monkey (and human) SWRs, and the larger post-ripple wave compared to those in mice. But, a few models rose to the top straightaway and performed even better with modest “top up” training! 📈Now I’m curious how the #opensource toolbox will perform on human hippocampal data. ……..➡️👩‍🔬both senior authors and one lead author were #womenInSTEM working across two continents, and the original multi-model testing was formulated as a hackathon that included #diverserepresentation ! #neuroai #ann #cnn #neuroscience #hippocampus #HippocampalReplay #internationalwomensday
@tyrell_turing may the vest man win.
Pssst! @saman just defended his PhD! 🎉🍾And that other place shouldn't get all the news, right? Right. So here's him during the defense (so many nice cell groups), and getting a surprise after the successful defense. He did a spectacular job! #phd #neuroscience #hippocampus #sciart

@teixi This is an important read! And you have to give it to the author for walking the walk.
(Openephys’ Voigt). How can we make services accessible for the community? It is, as he notes, mostly tied to industry products.

Also this;
“Putting the reluctance of individual scientists aside, adopting a culture of expertise will also require some shifts in the field. The current funding and publishing system punishes specialization and undervalues technical expertise. For example, most published papers have one (or at best a few) first and last authors. As long as we hang on to the idea of singular intellectual ownership as the main currency in neuroscience, people are incentivized to shoulder as much of their own project as they can rather than spending significant time helping someone else’s. A more granular means for giving credit and attribution — one that acknowledges that neuroscience is a team sport — would improve scientific progress.”

» #neuroscience has become so broad & technically sophisticated that individual researchers can no longer fully understand the technical foundations of their experiments.

The average #systemsneuroscience project, for example, requires in-depth knowledge of animal #surgery #mechanical #optical & #electrical #engineering #statistics and #computerscience «

https://www.thetransmitter.org/systems-neuroscience/why-and-how-we-need-to-professionalize-neuroscience/

#neurodon
#neurobuzz
#systemsneuro

Why (and how) we need to professionalize neuroscience

Moving away from the field’s do-it-yourself ethos and embracing professional technical expertise will make research more efficient.

The Transmitter: Neuroscience News and Perspectives
@seeingwithsound Yes!! As in, I can imagine more progress when research like this appreciates (ie recognizes) and expands on multisensory research! “Although it has been long been recognized that sensory cortices are not driven solely by bottom-up sensory inputs—the first single unit recordings reported attentional modulation of auditory responses in the cat [9]—there has recently been growing recognition of the importance of non-sensory responses in primary visual cortex (V1), such as those related to locomotion, arousal, and body movements [10–12].”