Dan Bose

@[email protected]
219 Followers
306 Following
37 Posts

Scientist (enhancers, eRNAs and chromatin), Sir Henry Dale Fellow; bike-fettling, bird-watching, accordion-troubling american-ophile

www.bose-lab.org
Orcid ID: 0000-0002-0276-6486

(still on twitter @danbose)

Starting up in science: https://www.nature.com/immersive/d41586-021-02563-x/index.html

Dan BoseAug 22, 2024
Show threadAli TwelvetreesAug 22, 2024
@steveroyle I am unlikely to ever even be a Fellow, but they do fund my team at the moment and honestly this is so profoundly disappointing. Of course no one else had the same level as experience as Nurse at interview, no one else had been given that much power for so long. It’s really time to step aside…
Dan BoseAug 22, 2024
Stephen RoyleAug 22, 2024

The Guardian reports that Paul Nurse is set to become President of the Royal Society again. Issues: holding the role twice is unprecedented, role never held by a woman, Nurse would be 81 by the end of term, outsized influence of Nurse on UK science.

https://www.theguardian.com/science/article/2024/aug/22/row-at-uk-royal-society-over-possible-re-election-of-former-president

Row at Royal Society over bid to re-elect former president to head ‘boys’ club’

Exclusive: Fellows divided as council reportedly puts forward Sir Paul Nurse for role never held by a woman

The Guardian
Show threadDan BoseAug 15, 2024
Importantly, the large C-terminal tail of CBP contains two adjacent IDRs with different sequence properties and competing positive and negative effects on condensate formation. The presence of -ve IDR is required to balance the +ve IDR.
Show threadDan BoseAug 15, 2024
We've known for many years that #CBP (and #p300) form nuclear bodies. The formation of these condensates can regulate activity and transcriptional outputs. But what is the role of individual IDRs in driving these processes?
Show threadDan BoseAug 15, 2024
This was a super effort by our team, special mention to Nic Carruthers for her work to HaloTag endogenous CBP and amazing collaborators @TwelvetreesLab & @TimCraggs
Show threadDan BoseAug 15, 2024
This allows condensate behaviour to respond to different inputs, such as lysine #acetylation in IDRs in other CBP domains. It can help to explain how #transcription factors binding to different regions of CBP differentially regulate CBP activity. #enhancers #generegulation #llps #chromatin #imaging #biochemistry #molecularbiology #CellBiology
Dan BoseAug 15, 2024
Bit late posting this here: Out now on #biorxiv: our grad student Katie took a deep dive into how different #IDRs affect the behaviour of #CBP #condensates in the nucleus. https://www.biorxiv.org/content/10.1101/2024.06.04.597392v2
Dan BoseAug 15, 2024
Show threadStephen RoyleAug 15, 2024
@scholpp_lab_LSI @CellySally @jamesbriscoe @amjeve have a look at this guide https://quantixed.org/2024/08/14/exodus-moving-to-mastodon/ there's a tip there to enrich your feed.
Your choice of server doesn’t matter (well, it does, but in terms of who you can see/speak to it usually doesn’t).
Migration is easy if you want to switch.
Exodus: moving to Mastodon – quantixed

Dan BoseDec 7, 2023
Mathieu Quesnel-VallièresNov 14, 2023

If you wonder what splice isoforms exist for your gene(s) of interest, or if you are interested in exploring tissue/cancer-specific splicing, we have a new tool for that.

#RNA #splicing #cancer

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad1043/7416386?login=false

MAJIQlopedia: an encyclopedia of RNA splicing variations in human tissues and cancer

Abstract. Quantification of RNA splicing variations based on RNA-Sequencing can reveal tissue- and disease-specific splicing patterns. To study such splicing va

OUP Academic
Dan BoseNov 14, 2023
Great to see this out- ABC was a great resource but this looks even better- was super interested to hear about it at #EMBOenhanceropathies a couple of weeks back #enhancers #generegulation https://www.biorxiv.org/content/10.1101/2023.11.09.563812v1