Mastodawn

Title: Enhancer Remodeling by OTX2 Directs Specification and Patterning of Mammalian Definitive Endoderm

🔍 OTX2 is critical for definitive endoderm patterning.

#OTX2 #DevelopmentalBiology #Endoderm #GeneRegulation #Pub2Post https://tnyp.me/s3IJY0xx/m

🌀 How does an embryo’s genome “wake up” and begin steering development on its own?

🔗 Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.017

📚 CSBJ: https://www.csbj.org/

#GeneRegulation #EmbryonicDevelopment #ChromatinBiology #Epigenetics #DevelopmentalBiology #Genomics #CellBiology

CSBJ Oct 18

🧬 Can cells “remember” their identity without changing their DNA?

🔗 Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.034

📚 CSBJ: https://www.csbj.org/

#Epigenetics #Chromatin #GeneRegulation #DNA #MolecularBiology #SyntheticBiology #CellEngineering #Genomics #SystemsBiology #DNAmethylation

Boas Pucker Sep 23

🌾 New #preprint!
"Evolutionary Rewiring of Anthocyanin Biosynthesis Pathway in Poaceae" 🎨

We show how grasses have independently restructured their anthocyanin biosynthesis pathway via:
🔹 Gene loss
🔹 Regulatory shifts
🔹 Convergent evolution

A case study in how flexible plant metabolic pathways really are.

🔗 https://doi.org/10.1101/2025.09.21.677584

#PlantScience #Evolution #Bioinformatics #GeneRegulation #Anthocyanins #Poaceae #OpenScience
@PuckerLab @samnm

Evolutionary Rewiring of Anthocyanin Biosynthesis Pathway in Poaceae

Poaceae is a species-rich family of plants in the monocots harboring many important crop species. As grasses, these plants lack striking flowers that are typically pigmented by anthocyanins. Here, we investigated the anthocyanin biosynthesis genes in Poaceae and characterized several striking patterns. (1) An independently evolved MYB lineage (ncaMYB) is responsible for the regulation of the anthocyanin biosynthesis in Poaceae. (2) The independently evolved BZ2 lineage replaced the otherwise widespread TT19/An9 lineage as anthocyanin-related glutathione S-transferase in Poaceae. (3) The anthocyanin biosynthesis genes ANS, arGST (BZ2), and the anthocyanin biosynthesis activating MYB (ncaMYB) appear to be absent from the genus Brachypodium. These observations could be explained by a loss of the anthocyanin biosynthesis at the basis of the Poaceae, followed by an evolutionarily independent regain and again a loss of the anthocyanin biosynthesis in Brachypodium. ### Competing Interest Statement The authors have declared no competing interest.

bioRxiv

PLOS Biology Sep 16, 2025

Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. In this #PLOSBiology Unsolved Mystery, Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.
https://plos.io/3VjfjWI

Why does the m6A writer complex require so many proteins?

Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation.

Daniel Hoffmann 🌼Sep 12, 2025

Profound study on #geneRegulation in E. coli: #transcriptionFactors generally stabilize interaction with RNA polymerase and thus reduce expression range across promoters -> better maintenance of homeostasis. https://www.science.org/doi/abs/10.1126/science.adv2064

jobRxiv Sep 7, 2025

Postdoctoral Research Fellow
UBC School of Biomedical Engineering

The SBME at UBC (Canada) is hiring two (2) full-time Postdoctoral Research Fellows in the de Boer Lab for 16 month terms.

See the full job description on jobRxiv: https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/

#biomedicalengineering #generegulation #genomics #mac...
https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/?fsp_sid=2195

Postdoctoral Research Fellow

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

jobRxiv Aug 31, 2025

Postdoctoral Research Fellow
UBC School of Biomedical Engineering

The SBME at UBC (Canada) is hiring two (2) full-time Postdoctoral Research Fellows in the de Boer Lab for 16 month terms.

See the full job description on jobRxiv: https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/

#biomedicalengineering #generegulation #genomics #mac...
https://jobrxiv.org/job/ubc-school-of-biomedical-engineering-27778-postdoctoral-research-fellow-2/?fsp_sid=1859

Postdoctoral Research Fellow

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

@Co_Biologists Aug 15, 2025

Our next Development Presents webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller and Marlies Oomen, and chaired by James Gahan.

Will you be attending?

📆 27 August, 15:00 BST (UTC+1)

#DevPres #GeneRegulation #Genes #DevelopmentalBiology #Learning #Education #Biology #Science