Uli Schwarz-Linek

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Structural biologist at the University of St Andrews. Host-pathogen interactions - Gram-positive bacteria - Streptococcus pyogenes #GroupAStrep - Rift Valley fever phlebovirus #RVFV - #proteins - #ExtracellularMatrix - adhesins - #NMR - #cryoEM novice - #crystallography
ORCIDhttps://orcid.org/0000-0003-0526-223X
About to finish #PhD in molecular microbiology/virology? Join us as #postdoc at the BSRC in St Andrews and work with Michael Nevels and me to study mechanisms underlying the devastating synergy of #GroupAStrep and #ChickenPox co-infections. Full details: https://www.vacancies.st-andrews.ac.uk/Vacancies/W/4582/0/391937/889/research-fellow-ar2823mr
Research Fellow – AR2823MR

Research Fellow – AR2823MR , School of Biology, Biomedical Sciences Research Complex, Salary: £37,099 - £44,263 per annum, Fixed Term: 12 months, Start: 1 September 2023 or as soon as possible thereafter , <p style="text-align: justify;"> Bacterial-viral co-infections are a widely recognised clinical phenomenon, often causing more severe symptoms and complicating treatment. The underlying pathogenicity mechanisms are poorly understood. This project will investigate how innate immune and inflammatory responses to viral infections induce changes in host cells that render them more susceptible to bacterial infection. Specifically, the project will address how infections with human cytomegalovirus and varicella zoster virus, both members of the herpesvirus family, affect the ability of group A streptococci to adhere to and invade human cells.  </p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"> We wish to recruit a postdoctoral Research Fellow to pursue this project. The successful applicant will have a PhD degree in the fields of virology, microbiology, or related disciplines with a strong interest in studying host-pathogen interactions using cellular and molecular approaches.   </p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"> This full-time post is available from 1st September 2023 for initially one year.</p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"> The project will be based in the Nevels and Schwarz-Linek laboratories in the Biomedical Sciences Research Complex at the University of St Andrews.   </p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"> Further information and informal enquiries may be directed to Dr Michael Nevels (<a href="mailto:[email protected]" target="_blank">[email protected]</a>) and Dr Uli Schwarz-Linek (<a href="mailto:[email protected]" target="_blank">[email protected]</a>).   </p> <p style="text-align: justify;"> </p> <p style="text-align: justify;">Applications are particularly welcome from women, people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented in professional posts at the University.   </p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"> Equality, diversity and inclusion are at the heart of the St Andrews experience. We strive to create a fair and inclusive culture demonstrated through our commitment to diversity awards (Athena Swan, Carer Positive, LGBT Charter, Race Charters and Stonewall). We celebrate diversity by promoting profiles of BAME, LGBTIQ+ staff and supporting networks including the Staff BAME Network; Staff with Disabilities Network; Staff LGBTIQ+ Network; and the Staff Parents & Carers Network. Full details available online: <a href="https://www.st-andrews.ac.uk/hr/edi/. " target="_blank">https://www.st-andrews.ac.uk/hr/edi/.</a></p> <p style="text-align: justify;"> </p> <p style="text-align: justify;"><strong>Please quote ref: AR2823MR</strong></p> <p style="text-align: justify;"><strong> </strong></p> <p style="text-align: justify;"><strong>Closing Date: 16 June 2023</strong></p> <p style="text-align: justify;"><strong> </strong></p> <p style="text-align: justify;"><strong>Further Particulars: <a href="https://www.vacancies.st-andrews.ac.uk//ViewAttachment.aspx?enc=jmxpV+AcVus8i/wvT3FZXrrCOvCUGNWd9uca/tGZrAI1OaVYgAVgEWg8BgadY6R/Hu+p9n0akqd1K8esp4wHyIzSnGokGxp09cHj2kpgvuzd3FQza9uwrLLurtSoRTyH" target="_blank" title="AR2823MR FPs.doc">AR2823MR FPs.doc</a></strong></p> <p style="text-align: justify;"><strong> </strong></p> <p style="text-align: justify;">School of Biology</p> <p style="text-align: justify;">Biomedical Sciences Research Complex</p> <p style="text-align: justify;">Salary: £37,099 - £44,263 per annum</p> <p style="text-align: justify;">Fixed Term: 12 months</p> <p style="text-align: justify;">Start: 1 September 2023 or as soon as possible thereafter     </p>, Working Hours : Full Time Job Family : Academic Research School/Unit : School of Biology ,

The sun’s performance gets a low grade due to brevity, a mere 6h52min in the East Neuk of Fife today. I am also done with my work for the day and year, all exam scripts marked. Holiday mode activated 🥃.

Hi! #introduction to my #science:

My group uses #StructuralBiology (#NMR, #Crystallography, #CryoEM) and cell-based experiments to study protein interactions at the host:pathogen interface.

We study how surface #proteins of Gram-positive bacteria, mainly TIE proteins (chemical harpoons) and M proteins of #GroupAStrep, interact with extracellular matrix and host cells.

Our other interest is the #RiftValleyFever phlebovirus NSs protein. Also dabble in protein engineering and tagging.