Congratulations to Claudia Höbartner on being awarded the prestigious Albrecht-Kossel-Preis of the @gdch at #Biochemistry2026. A very well deserved honor.

Claudia gave an amazing award lecture on "Enzymes made of DNA and RNA".

#Biochemistry #Chemistry #ChemBio #RNA #DNA
CC: @GDCh_BioChem

Understanding the thioredoxin system is key to understanding cellular RedOx homeostasis.

Congratulations to Lukas Zeisel on being awarded one of the @GDCh_BioChem Young Scientist Awards for his work in the group of Oliver Thorn-Seshold in this field.

https://pubs.acs.org/doi/abs/10.1021/jacs.3c11153
#Biochemistry #Chemistry #ChemBio #Sensor #Fluorescence

Can CO2 be fixed into useful feedstock chemicals by enzymes?

Congratulations to Frederik Schmidt on being award one of the @GDCh_BioChem Young Scientist Awards for his work on the biochemical and structural characterization of an iron nitrogenase with potential for this application.

https://www.nature.com/articles/s41594-023-01124-2
#Biochemistry #Chemistry #StructuralBiology #CO2Fixation

GTPases have long been considered key examples of undruggable proteins. While this has been overcome for K-Ras using #CovalentInhibitors, for many other family member #DrugDevelopment has not been shown.

Congratulations to Johannes Morstein on winning one of the @GDCh_BioChem Young Scientist Awards for his work addressing this challenge by identifying druggable, allosteric pockets in several GTPases.

https://www.cell.com/cell/fulltext/S0092-8674(24)00908-5
#Biochemistry #ChemBio #GTP #GTPases #Chemistry
CC: @gdch

How can the concentration of glutathione be monitored with subcellular precision?

Congratulations to Sarah Emmert on receiving one of the @GDCh_BioChem Young Scientist Awards for her work in the lab of Pablo Rivera-Fuentes on addressing this question with fluorescent sensors.

https://www.nature.com/articles/s41557-023-01249-3
#Biochemistry #Fluorescence #Sensors #Chemistry #ChemBio #Award

Can the functions of #metalloenzymes be further improved using non-canonical amino acids?

In her talk at #Biochemistry2026, Alexandra Deliz Liang talked about the usage of genetic code expansion in order to improve the activity of metalloenzymes using e.g. hydrophobic tuning.

https://www.biorxiv.org/content/10.1101/2025.02.09.636911v1
#Chemistry #ChemBio #Biochemistry #BioinorganicChemistry #ProteinEngineering
CC: @gdch, @GDCh_BioChem

STAT4 is an important target in autoimmune disease research.

In this talk at #Biochemistry2026, Thorsten Berg talked about the discovery of potent inhibitors of STAT4. He gave exciting insights into prodrugs for phosphates and phosphonates.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202504420
#Chemistry #DrugDiscovery #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem

Insightful talk by Clemens Richert at #Biochemistry2026. He talked about his group’s work on optimized #antivirals. He gave exciting insights into the optimization of prodrugs of nucleotides #ProTides.

#Biochemistry #Chemistry #ChemBio #Virus #DrugDiscovery
CC: @gdch, @GDCh_BioChem

Insightful presentation by Pierre Stallforth at #Biochemistry2026. He talked about their hunt for new natural products from unusual sources including those produced during amoebal predation of bacteria and those identified in ancient samples.

https://pubs.acs.org/doi/10.1021/jacs.5c17955
https://pubs.acs.org/doi/full/10.1021/jacs.5c14335
#Biochemistry #ChemBio #Chemistry #NaturalProducts #Paleogenomics
CC: @gdch, @GDCh_BioChem

Great talk by Akane Kawamura at #Biochemistry2026. She talked about her group's exciting work on the #Biochemistry of JmjC demethylases with important implications for #epigenetics. Exciting insights into arginine demethylation.

https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14586

She also talked about the potential of these enzymes in #DrugDiscovery including the discovery of #CovalentInhibitors for KDM5.

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201810179
#Chemistry #ChemBio #Biochemistry
CC: @gdch, @GDCh_BioChem