#SSRI Fluvoxamine could reduce clinical deterioration of pt.s with #Covid ➡️ increasing nighttime plasma levels of #Melatonin as it is an #AntiOxidant & #AntiInflammatory in addition to being a chronobiotic.
Melatonin is a #Hormone of darkness . Light at night can suppress it & therefore reducing its anti inflammatory impact. Exogenous melatonin must be taken at the same time & it’s purity validated. Dose 3-10 mg & > upwards.
Start low & titrate upwards.
#Sleep #Wake #Circadian #Rhythms

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe condition characterized by post-exertional #Neuroimmune exhaustion (PENE) accompanied by #Neurological, #Immunological, #Gastrointestinal (GI), & #Mitochondrial disturbances […]i affecting 17 million to 24 million people (2). ME/CFS is heterogeneous not only in Sx presentation but also illness trajectories, which can be worsening, plateauing, improving, or relapsing-remitting”
https://www.science.org/doi/10.1126/science.abo1261
#MECFS #ChronicIllness

A privilege to be invited by the students interested in Health Care & research to talk all things sleep. The open discussion ranged from #Sleep & #Brain, # ExtractiveResearch Methodology & #COVID. The #teens are getting less than their recommended sleep (9 hours)across the 🌍. We talked about the importance of self care & #RadicalRest in the age of the #Pandemic & how sleep shapes who we become as human beings. Also, introduced them to the brilliant work of the Iranian #artist Maryam Ashkanian.

Neuroinflamation via the 😡 microglia cells hypothesis:
In #ME|CFS & #LongCOVID
these cells become hypersensitive & hyper activated & it takes very little to
set them off.
Even the tiniest activity leads to a cytokine storm➡️ hyper-inflammation ➡️state of chronic sickness.
Also,
Activation of hypothalamus (brain’s innate immune sys. temp control etc.) can trigger cytokines ⬆️ inflammatory molecules via infection, toxins, stress, temp fluctuations- Jarred Younger

#RadicalRest is recommended