In this episode we caught up with @PSarkies from University of Oxford Biochemistry to talk about his work on #Transgenerational Inheritance of #Epimutations. #chromatin #epigenetics #podcast @epigenetics
Listen here:
https://activemotif.com/podcasts#peter-sarkies
A new #preprint #OpenScience #PeerReview by PCI Ecology: Delattre T, Memah M-M, Franck P, Valsesia P, Lavigne C (2023) Best organic farming deployment scenarios for pest control: a modeling approach. bioRxiv, 2022.05.31.494006, ver. 2 peer-reviewed and recommended by PCI Ecology. https://doi.org/10.1101/2022.05.31.494006
Recommended by Sandrine Charles for PCI Ecology based on published reviews by Lionel Hertzog, Julia Astegiano and Sylvain Bart #OpenScience https://doi.org/10.24072/pci.ecology.100425
Author summary Transposable elements (TEs) are engines of evolution over short and long evolutionary time scales and have played crucial roles in pathogen evolution. The impacts of TEs are multifaceted, ranging from creating adaptive sequence variants, gene disruptions, chromosomal rearrangements or even triggers of genome expansions. As a defense, pathogen genomes have evolved sophisticated mechanisms to silence or mutate TEs. Pathogens have also benefited from TEs thanks to altered virulence genes and increased antifungal resistance. How TEs cope with genomic defenses and expand in genomes (i.e., cause TE bursts) remains poorly understood though. We analyzed over a dozen high-quality genomes of a fungal wheat pathogen species, which has recently experienced TE reactivations. We reconstructed the evolutionary history of many TEs by building phylogenetic trees. Using this approach, we identified "invasion routes", i.e., tracking TE copies that constitute the most likely ancestors of renewed activity of TEs (i.e. a bursts). Our work showed that specific features, in particular the proximity to genes, were likely important drivers leading the reactivation of TEs.
Transforming an existing phenotypic classification of viruses into one based on evolutionary relationships that can accommodate the vast number of viruses characterized in metagenomics and environmental studies is an ongoing challenge. This Consensus View explains how such a taxonomy can be expanded to encapsulate viral diversity and to recognize independent biological origins of different virus groups.
#GeneRegulation digest #4:
🧬 New role of histone tails in nucleosome remodelling https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad079/7034407
🧬 TFBSs under accelerated #evolution in primates https://www.nature.com/articles/s41467-023-36421-3
🧬 Review of IDRs in #transcription regulators https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(23)00008-7
🧬 CpG islands & protection of genes from premature transcription termination https://www.nature.com/articles/s41467-023-36236-2
🧬 Regulation of #enhancers by DNA #methylation https://www.sciencedirect.com/science/article/pii/S1097276523000400
🧬 H2A-H2B & short-term memory of #chromatin states https://www.sciencedirect.com/science/article/pii/S0092867423000077
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