3Brain

@[email protected]
23 Followers
23 Following
27 Posts

We empower researchers to explore #intelligent biological networks by linking them to #information technology.

#blogging about #neuroscience #networks #brain #semiconductor-based biointerfaces

#organizing the Massimo Grattarola Award to help young researchers get their ideas funded

Websitewww.3brain.com
Scicomm bloghttps://www.3brain.com/pin/explorer-series
Linkedinhttps://ch.linkedin.com/company/3brain
3BrainJun 27, 2023

🚨 Are you at #MPS2023 and curious about cutting-edge brain-on-chip #biointerfaces?

Come by and have a chat with us! No matter if brain #organoids, #spheroids or acute tissue #slices, we have so much to show! 🔬

More about @3Brain's technology:

https://www.3brain.com/technology/accura-3d

Accura 3D

Discover our first-in-class 3D CMOS chip design at the heart of a revolutionary cell-electronic interface for investigating electroactive human tissues and 3D brain organoids

3BrainJun 26, 2023

Next week: Come explore our groundbreaking 3D microchips at #ISSCR2023 in Boston, USA!

No matter if #iPSC, primary neurons, or brain #organoids, @3Brain's #biointerface technology is revolutionizing neuroscience and advancing #stem cell research.

#drugdiscovery #screening

3BrainJun 26, 2023
Chen et al. report about #LARAs, a new #astrocyte subtype with excessive lipid accumulation, driving #epilepsy progression. Using @3Brain's high-res #biointerface tech, they probe how APOE4 polymorphism influences #epileptiform electrical #activities.
➡️ https://www.nature.com/articles/s41593-023-01288-6
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

Chen et al. describe a new subtype of reactive astrocyte formed by APOE-mediated lipid accumulation in individuals with epilepsy and mouse models. These reactive astrocytes aggravate seizure symptoms and could serve as new therapeutic targets for epilepsy.

Nature
3BrainMay 24, 2023
Giasante et al. found PCDH19-negative hyperexcitable neurons and global reduction in #network activity, offering new insights into this complex #neurodevelopmental disorder.
Aided by 3Brain’s high-resolution #biointerface technology!
Check out:
https://www.nature.com/articles/s41380-023-02022-1
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression - Molecular Psychiatry

Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 expression in neurons is considered a key determinant of the disorder; however, how PCDH19 mosaic expression affects neuronal network activity and circuits is largely unclear. Here, we show that the hippocampus of Pcdh19 mosaic mice is characterized by structural and functional synaptic defects and by the presence of PCDH19-negative hyperexcitable neurons. Furthermore, global reduction of network firing rate and increased neuronal synchronization have been observed in different limbic system areas. Finally, network activity analysis in freely behaving mice revealed a decrease in excitatory/inhibitory ratio and functional hyperconnectivity within the limbic system of Pcdh19 mosaic mice. Altogether, these results indicate that altered PCDH19 expression profoundly affects circuit wiring and functioning, and provide new key to interpret DEE9 pathogenesis.

Nature
3BrainMay 17, 2023

Exciting news!

@3Brain's @DenizPhd will soon come to Canada! We'll be showcasing our innovative high-density 3D #biointerface technology, a game-changer in neural complexity research.

Can't wait to connect at the 16th @CAN_ACN conference!
#3Brain #BrainTech #

3BrainMay 3, 2023

Interested in groundbreaking #biointerfaces for functional recording of #neuronal activity in 2D and #3D model systems? #organoids

Meet @denizphd at #FRM2023 ☀️ Algarve ☀️ !

Also: If you are a #neuroscience PhD/PostDoc currently looking for opportunities, feel free to come by!

3BrainApr 5, 2023

What can #biointerfaces do for functional screening in #stemcells and #organoids?

Are you interested in studying emerging behaviors in cellular #networks?

We got just the right tech for you!

Meet us at iPSZurich on the 14th of April to get a glimpse into the #future

3BrainMar 28, 2023

Can #exosomes from #nasal fluid be used as diagnostic tool for #Alzheimer's disease?

Check out the wonderfully creative pre-print use of our high-resolution #biointerface technology from Sang Seong Kim and colleagues from Hanyang University:
https://www.biorxiv.org/content/10.1101/2023.01.24.525465v1
#biomarkers

3BrainMar 22, 2023

#GoeMe23: Let's talk about the versatility of #biointerfaces for your research!

Biointerface technologies promise label-free, functional recording of #neuronal activity for #organoids, acute tissue slices, and primary cell culture.

We are excited to be exhibiting our innovative technology at The 15th Göttingen Meeting of the German Neuroscience Society.

Come by booth Nr. 18 to chat about #functional recording, #phenotypic screening, #connectivity, and much more!

3BrainMar 16, 2023

What #functional perturbations drive #neurodegenerative disease?

Meet us at #ADPD23 to see how our first-in-class 3D chip can grant unparalleled access to the #microcircuitry of your in vitro/ex vivo model systems & yield novel #biological insights.

#biointerface #organoids #alzheimer #parkinson #epilepsy #stemcells