3BrainChen et al. report about #LARAs, a new #astrocyte subtype with excessive lipid accumulation, driving #epilepsy progression. Using @3Brain's high-res #biointerface tech, they probe how APOE4 polymorphism influences #epileptiform electrical #activities.
➡️ https://www.nature.com/articles/s41593-023-01288-6
➡️ https://www.nature.com/articles/s41593-023-01288-6
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience
Chen et al. describe a new subtype of reactive astrocyte formed by APOE-mediated lipid accumulation in individuals with epilepsy and mouse models. These reactive astrocytes aggravate seizure symptoms and could serve as new therapeutic targets for epilepsy.