Lukas VFN 🇪🇺Nov 26, 2023

Dynamic bio-interface between mussel tissue and byssus plays important role in quick release https://phys.org/news/2023-11-dynamic-bio-interface-mussel-tissue-byssus.html

A strong quick-release #biointerface in mussels mediated by serotonergic cilia-based adhesion https://www.science.org/doi/10.1126/science.adi7401

"#Mussels use #byssus threads (known commonly as a beard) to attach themselves to solid objects such as rocks. The #mussel byssus has been extensively studied due to their unique ability to connect nonliving material to living tissue and to disconnect on demand."

Dynamic bio-interface between mussel tissue and byssus plays important role in quick release

A team of chemists at McGill University, working with a colleague from Charité-Universitätsmedizin, in Germany, has uncovered part of the process used by mussels to bind to rocks and to quickly release from them when conditions warrant.

Phys.org
katch wreckNov 16, 2023

"The sheet surfaces are in intimate adhesive contact with billions of motile epithelial #cilia that control #biointerface strength and stem release through their collective movement, which is regulated neurochemically. We posit that this may involve a complex sensory pathway by which sessile #mussels respond to environmental stresses to release and relocate."

https://www.science.org/doi/10.1126/science.adi7401

jobRxivAug 19, 2023

Postdoctoral Fellow - Mechanobiology

CNRS

Come join us in the #BioInterface group as a postdoc to work on #curvature sensing mechanisms

See the full job description on jobRxiv: https://jobrxiv.org/job/cnrs-27778-postdoctoral-fellow-mechanobiology/?feed_id=55711

#ScienceJobs #hiring #research #mechanobiology, #postdoc
Mulhouse #France #PostdoctoralFellow
https://jobrxiv.org/job/cnrs-27778-postdoctoral-fellow-mechanobiology/?feed_id=55711

Postdoctoral Fellow - Mechanobiology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
jobRxivJul 29, 2023

Postdoctoral Fellow - Mechanobiology

CNRS

Come join us in the #BioInterface group as a postdoc to work on #curvature sensing mechanisms

See the full job description on jobRxiv: https://jobrxiv.org/job/cnrs-27778-postdoctoral-fellow-mechanobiology/?feed_id=52688

#ScienceJobs #hiring #research #mechanobiology, #postdoc
Mulhouse #France #PostdoctoralFellow
https://jobrxiv.org/job/cnrs-27778-postdoctoral-fellow-mechanobiology/?feed_id=52688

Postdoctoral Fellow - Mechanobiology

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
3BrainJun 26, 2023

Next week: Come explore our groundbreaking 3D microchips at #ISSCR2023 in Boston, USA!

No matter if #iPSC, primary neurons, or brain #organoids, @3Brain's #biointerface technology is revolutionizing neuroscience and advancing #stem cell research.

#drugdiscovery #screening

3BrainJun 26, 2023
Chen et al. report about #LARAs, a new #astrocyte subtype with excessive lipid accumulation, driving #epilepsy progression. Using @3Brain's high-res #biointerface tech, they probe how APOE4 polymorphism influences #epileptiform electrical #activities.
➡️ https://www.nature.com/articles/s41593-023-01288-6
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy - Nature Neuroscience

Chen et al. describe a new subtype of reactive astrocyte formed by APOE-mediated lipid accumulation in individuals with epilepsy and mouse models. These reactive astrocytes aggravate seizure symptoms and could serve as new therapeutic targets for epilepsy.

Nature
3BrainMay 31, 2023
Using @3Brain's high-resolution #biointerface technology, Monteverdi et al. unveiled a significant frequency dependence and spatial #anisotropy in cerebellar network processing, expanding our current understanding of these complex #circuits.
#cerebellum
https://www.mdpi.com/2227-9059/11/5/1475
Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings

The cerebellum is one of the most connected structures of the central nervous system and receives inputs over an extended frequency range. Nevertheless, the frequency dependence of cerebellar cortical processing remains elusive. In this work, we characterized cerebellar cortex responsiveness to mossy fibers activation at different frequencies and reconstructed the spread of activity in the sagittal and coronal planes of acute mouse cerebellar slices using a high-throughput high-density multielectrode array (HD-MEA). The enhanced spatiotemporal resolution of HD-MEA revealed the frequency dependence and spatial anisotropy of cerebellar activation. Mossy fiber inputs reached the Purkinje cell layer even at the lowest frequencies, but the efficiency of transmission increased at higher frequencies. These properties, which are likely to descend from the topographic organization of local inhibition, intrinsic electroresponsiveness, and short-term synaptic plasticity, are critical elements that have to be taken into consideration to define the computational properties of the cerebellar cortex and its pathological alterations.

MDPI
3BrainMay 24, 2023
Giasante et al. found PCDH19-negative hyperexcitable neurons and global reduction in #network activity, offering new insights into this complex #neurodevelopmental disorder.
Aided by 3Brain’s high-resolution #biointerface technology!
Check out:
https://www.nature.com/articles/s41380-023-02022-1
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression - Molecular Psychiatry

Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 expression in neurons is considered a key determinant of the disorder; however, how PCDH19 mosaic expression affects neuronal network activity and circuits is largely unclear. Here, we show that the hippocampus of Pcdh19 mosaic mice is characterized by structural and functional synaptic defects and by the presence of PCDH19-negative hyperexcitable neurons. Furthermore, global reduction of network firing rate and increased neuronal synchronization have been observed in different limbic system areas. Finally, network activity analysis in freely behaving mice revealed a decrease in excitatory/inhibitory ratio and functional hyperconnectivity within the limbic system of Pcdh19 mosaic mice. Altogether, these results indicate that altered PCDH19 expression profoundly affects circuit wiring and functioning, and provide new key to interpret DEE9 pathogenesis.

Nature
3BrainMay 17, 2023

Exciting news!

@3Brain's @DenizPhd will soon come to Canada! We'll be showcasing our innovative high-density 3D #biointerface technology, a game-changer in neural complexity research.

Can't wait to connect at the 16th @CAN_ACN conference!
#3Brain #BrainTech #

3BrainMay 10, 2023

Unraveling epilepsy mysteries w/ @3Brain's cutting-edge #biointerface tech! 🧠🌀

A study by Boucher-Routhier et al. ⬇️ used #GANs to analyze rare #spiral wave activity in cortical networks, key to understanding epilepsy.

Our high-res #microchip tech enabled detailed monitoring, paving the way for new treatment insights! 🚀🔬 #seizure #neuralcomplexity

Please read:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039524/

A deep generative adversarial network capturing complex spiral waves in disinhibited circuits of the cerebral cortex

In the cerebral cortex, disinhibited activity is characterized by propagating waves that spread across neural tissue. In this pathological state, a widely reported form of activity are spiral waves that travel in a circular pattern around a fixed spatial ...

PubMed Central (PMC)