Forming Vesicles on Titan

Scientists are still debating exactly what shifts nature from chemical and physical reactions to living cells. But vesicles — small membrane-bound pockets of fluid carrying critical molecules — are a commonly cited ingredient. Vesicles help cluster important organic molecules together, increasing their chances of combining in the ways needed for life. Now scientists are suggesting that Titan, Saturn’s moon, could form vesicles of its own.

On Earth, molecules known as amphiphiles feature a hydrophilic (water-loving) end and a hydrophobic (water-fearing) one. When dispersed in water, amphiphiles crowd at the surface, placing their hydrophilic end in the water and their hydrophobic end outward toward the air. On Titan, the Cassini mission revealed organic nitrile molecules that behave similarly with methane rather than water.

Their two-sided structure means that these molecules — like Earth’s amphiphiles — will gather at the surface of Titan’s liquids. When methane rain falls on the Titan’s seas, the impact creates aerosol droplets that slowly settle back to the liquid surface. When that happens, the droplet’s molecular monolayer and the lake’s monolayer meet, enclosing the droplet’s contents in a double-layer of molecules that prevent contact between the droplet and the lake.

Within that newly-formed vesicle, all kinds of molecules can bump shoulders, creating new opportunities for complex chemistry. (Image credit: Titan – ESA/NASA/JPL/University of Arizona, illustration – C. Mayer and C. Nixon; research credit: C. Mayer and C. Nixon; via Gizmodo)

#biology #chemistry #fluidDynamics #physics #science #splashes #Titan #vesicle

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @PLOSBiology https://plos.io/3EfJsBp
MSP-tracker: A versatile vesicle tracking software tool used to reveal the spatial control of polarized secretion in Drosophila epithelial cells

How specific cargos are targeted to the apical and basolateral domains within epithelial cells is still unclear. This study develops a vesicle tracking software (MSP-tracker) and uses it to show that the secretory pathway in Drosophila follicle cells is more spatially organized than previously thought.

Researchers discover two #vesicle fusion mechanisms while studying vesicle movement in living #cells.

#endosomes #actin

https://phys.org/news/2024-04-vesicle-fusion-mechanisms-movement-cells.html

Researchers discover two vesicle fusion mechanisms while studying vesicle movement in living cells

Cells intake substances from the outside world by encapsulating them in vesicles called endosomes, which are subsequently transported throughout the cell. During the transport process, vesicles fuse with other intracellular organelles. However, observing this process is challenging in many cells due to their small size and the complexity of underlying regulatory mechanisms.

Phys.org

"..the oldest #eukaryote-bearing units already show species richness levels similar to those of the much younger & more heavily sampled Tonian period..these oldest eukaryotic assemblages show significant morphological disparity, particularly in #vesicle construction. These high levels of..species richness & morphological disparity suggest that although late Palaeoproterozoic units preserve our oldest record of #eukaryotes, the eukaryotic clade has a much deeper #history"

https://onlinelibrary.wiley.com/doi/full/10.1002/spp2.1538

RT @: Depletion of abundant #plasma #proteins for #extracellular #vesicle proteome characterization: benefits and pitfalls
by Sandrine Reymond et al @UNIGEnews @unige_en #proteomics #chromatography #EVs #biomarker

#OpenAccess
https://link.springer.com/article/10.1007/s00216-023-04684-w…

Adenosine is a molecule that binds to certain receptors in the body, called G protein-coupled receptors (GPCRs). When adenosine binds to these receptors, it activates two different types of GPCRs, called Gs and Gi. Adenosine is created from a molecule called ATP or adenosine triphosphate. This molecule is stored in a #vesicle in the #presynaptic #neuron. When an action potential occurs, the vesicle fuses with the presynaptic #membrane and releases ATP and glutamate.

#vesicle : a small bladderlike body in the substance of vegetable, or upon the surface of a leaf

- German: das Bläschen

- Portuguese: vesícula

- Spanish: vesícula

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#vesicle : a small bladderlike body in the substance of vegetable, or upon the surface of a leaf

- German: das Bläschen

- Portuguese: vesícula

- Spanish: vesícula

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#vesicle : a small bladderlike body in the substance of vegetable, or upon the surface of a leaf

- German: das Bläschen

- Portuguese: vesícula

- Spanish: vesícula

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#vesicle: a small bladderlike body in the substance of vegetable, or upon the surface of a leaf

- German: das Bläschen

- Portuguese: vesícula

- Spanish: vesícula

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Word of The Hour

Word of the Hour helps expand your vocabulary. Every hour, a new vocabulary word is featured along with translations into 10+ languages including French, German, Hindi, Italian, Portuguese, Spanish, and more. We are supported by our warm and welcoming community on Reddit.