What The #Pox? #Review of #Poxviruses Affecting #Humans, J Clin Virol.: https://www.sciencedirect.com/science/article/abs/pii/S1386653224000817?dgcid=rss_sd_all
This review examines various poxviruses affecting humans, with discussion of less commonly encountered Poxviridae members, including #pathogenesis, #epidemiology, and #diagnostic methods. Poxvirus #treatment is beyond the intended scope of this review and will not be discussed.
SAMD9 and SAMD9L are known restriction factors of poxviruses, but it is currently unknown if the SAMD9 gene family can restrict other viruses. This study demonstrates that SAMD9L, but not SAMD9, inhibits HIV-1 and other primate lentiviruses through a conserved Schlafen-like active site, thereby disrupting viral translation.
Virophages are viruses that infect giant viruses, typically resulting in a lower burst size for the giant virus. In our latest preprint we report virophage-like sequences associated with insect poxviruses.
Their genomes of these elements are really interesting. This also opens up the possibility that hyperparasitic viruses are associated with a much broader range of DNA viruses than is commonly thought.
Scientists have uncovered the mechanism by which poxviruses bypass cellular defenses and have identified existing drugs that can prevent this evasion. Researchers examining the methods poxviruses use to bypass human cell defenses have pinpointed a potentially more durable treatment strategy than wh
Widespread Distribution and Evolution of Poxviral Entry-Fusion Complex Proteins in Giant Viruses
Very nice recent minireview on poxvirus genomics and evolution:
Molecular Mechanisms of Poxvirus Evolution
Giuseppe Michieli
PLOS Biology
Frank Aylward
Matt Willemsen