🦠 Despondent In Dystopia 😷Sep 14, 2023

Question for #MedMastodon #medicalmastodon :

Is there a database to log post -COVID symptoms or sequelae that can be used for assessment or pattern recognition? I know there's things like VAERS for vax side effects, but what about things after illness?

Example: I'm 3.5 weeks past my negative test after 3 weeks of positive tests. I'm experiencing strange sensations throughout my body, like, you know that feeling when your stomach is churning? It feels like that, but throughout my whole body... like a "flutter/churn" thru my extremities and torso. The sensation can only be described like how those (somewhat inappropriate-looking) water wiggle snake toys from the 90s felt in your hand, but thru my whole body.

#PostCovid #LongCOVID #postcovidsequelae #covid #covid19

Show threadKirsty's Old AccountSep 12, 2023
@commentsandopi2
I was struck by the number of quotable quotes in that article! A must-read… ⬆️
#CovidIsNotOver #Covid19 #PostCovidSequelae #LongCovid #MaskUp #MasksMatter
Tom KindlonJul 30, 2023

“Here, we investigated the neural activities underlying COVID-19 related outcomes in a case-control study of mildly infected youth enrolled in a longitudinal study in Lombardy, Italy, a global hotspot of COVID-19.”

https://rb.gy/prz05

“Our results show persistent structural, functional and cognitive brain changes in key brain areas associated with olfaction and cognition.”

@longcovid #LongCovid #pwlc #PostCovid #PostCovid19 #postcovidsequelae #covid #covidbrain #CovidLong

Covid-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study

Coronavirus disease 2019 (COVID-19) has been associated with brain functional, structural, and cognitive changes that persist months after infection. Most studies of the neurologic outcomes related to COVID-19 focus on severe infection and aging populations. Here, we investigated the neural activities underlying COVID-19 related outcomes in a case-control study of mildly infected youth enrolled in a longitudinal study in Lombardy, Italy, a global hotspot of COVID-19. All participants (13 cases, 27 controls, mean age 24 years) completed resting state functional (fMRI), structural MRI, cognitive assessments (CANTAB spatial working memory) at baseline (pre-COVID) and follow-up (post-COVID). Using graph theory eigenvector centrality (EC) and data-driven statistical methods, we examined differences in ECdelta (i.e., the difference in EC values pre- and post-COVID-19) and volumetricdelta (i.e., the difference in cortical volume of cortical and subcortical areas pre- and post-COVID) between COVID-19 cases and controls. We found that ECdeltasignificantly between COVID-19 and healthy participants in five brain regions; right intracalcarine cortex, right lingual gyrus, left hippocampus, left amygdala, left frontal orbital cortex. The left hippocampus showed a significant decrease in volumetricdeltabetween groups (p=0.041). The reduced ECdelta in the right amygdala associated with COVID-19 status mediated the association between COVID-19 and disrupted spatial working memory. Our results show persistent structural, functional and cognitive brain changes in key brain areas associated with olfaction and cognition. These results may guide treatment efforts to assess the longevity, reversibility and impact of the observed brain and cognitive changes following COVID-19. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was funded by National Institutes of Environmental Health Sciences (NIEHS) grants numbers R01 ES019222, R01 ES013744, P30ES023515, and the European Union through its Sixth Framework Programme for RTD (contract number FOOD-CT-2006-016253). ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Written informed consent was obtained from parents and young adults, participants < 18 years provided written assent. Study procedures were approved by the Institutional Review Board of the University of California, Santa Cruz and the ethical committees of the University of Brescia, and the Icahn School of Medicine at Mount Sinai. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the author

medRxiv
Tom KindlonJul 23, 2023

Myopathy as a cause of #LongCovid fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology

https://t.ly/klcC_

“In addition to our previously published mitochondrial changes, inflammation, and capillary injury, we show now in muscle biopsies damage of terminal nerves and motor endplate with abundant basal lamina material”

@longcovid #postcovid #postcovid19 #postcovidconditon #postcovidsequelae #postcovidsyndrome #pwlc #CovidLong #CovidLonghaul #COVIDlonghauler

Show threadTom KindlonJul 21, 2023

2/

PrecisionLife, a computational biology company driving precision medicine in complex chronic diseases, has announced the results of its long COVID study, providing the first detailed genetic insights into the condition and its commonalities with other diseases, including #myalgicencephalomyelitis / #chronicfatiguesyndrome (ME/CFS).

http://surl.li/jhupk

@mecfs @longcovid #PostCovid #PostCovid19 #postcovidsequelae #pwlc #LongCovid #pwme #mecfs

PrecisionLife identifies genetic risk factors for long COVID

PrecisionLife, a computational biology company driving precision medicine in complex chronic diseases, has announced the results of its long COVID study, providing the first detailed genetic insights into the condition and its commonalities with other diseases, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

biopharma-reporter.com
Tom KindlonJun 4, 2023

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

https://www.mdpi.com/2077-0383/12/6/2123

“The finding that the longer the period from COVID-19 infection the worse the vascular impairment was surprising, as we expected inflammation burden associated with COVID-19 to decrease with time.”

@covid19 @longcovid #LongCovid #longcovid19 #PostCovid #PostCovid19 #postcovidsequelae #CovidLong #pwlc

Long-Term Adverse Effects of Mild COVID-19 Disease on Arterial Stiffness, and Systemic and Central Hemodynamics: A Pre-Post Study

COVID-19-associated vascular disease complications are primarily associated with endothelial dysfunction; however, the consequences of disease on vascular structure and function, particularly in the long term (>7 weeks post-infection), remain unexplored. Individual pre- and post-infection changes in arterial stiffness as well as central and systemic hemodynamic parameters were measured in patients diagnosed with mild COVID-19. As part of in-laboratory observational studies, baseline measurements were taken up to two years before, whereas the post-infection measurements were made 2–3 months after the onset of COVID-19. We used the same measurement protocol throughout the study as well as linear and mixed-effects regression models to analyze the data. Patients (N = 32) were predominantly healthy and young (mean age ± SD: 36.6 ± 12.6). We found that various parameters of arterial stiffness and central hemodynamics—cfPWV, AIx@HR75, and cDBP as well as DBP and MAP—responded to a mild COVID-19 disease. The magnitude of these responses was dependent on the time since the onset of COVID-19 as well as age (pregression_models ≤ 0.013). In fact, mixed-effects models predicted a clinically significant progression of vascular impairment within the period of 2–3 months following infection (change in cfPWV by +1.4 m/s, +15% in AIx@HR75, approximately +8 mmHg in DBP, cDBP, and MAP). The results point toward the existence of a widespread and long-lasting pathological process in the vasculature following mild COVID-19 disease, with heterogeneous individual responses, some of which may be triggered by an autoimmune response to COVID-19.

MDPI
Irish ME/CFS AssociationJun 4, 2023

“Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study”

https://www.bmj.com/content/381/bmj-2022-074425

“Up to 18% of individuals who were not vaccinated before infection had post-covid-19 condition up to two years after infection”

Interesting #LongCovid study from Switzerland

@longcovid #PostCovid #postCOVID19 #pwLC #postcovidsequelae #CovidLong #COVIDlonghauler

Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study

Objective To evaluate longer term symptoms and health outcomes associated with post-covid-19 condition within a cohort of individuals with a SARS-CoV-2 infection. Design Population based, longitudinal cohort. Setting General population of canton of Zurich, Switzerland. Participants 1106 adults with a confirmed SARS-CoV-2 infection who were not vaccinated before infection and 628 adults who did not have an infection. Main outcome measures Trajectories of self-reported health status and covid-19 related symptoms between months six, 12, 18, and 24 after infection and excess risk of symptoms at six months after infection compared with individuals who had no infection. Results 22.9% (95% confidence interval 20.4% to 25.6%) of individuals infected with SARS-CoV-2 did not fully recover by six months. The proportion of individuals who had an infection who reported not having recovered decreased to 18.5% (16.2% to 21.1%) at 12 months and 17.2% (14.0% to 20.8%) at 24 months after infection. When assessing changes in self-reported health status, most participants had continued recovery (68.4% (63.8% to 72.6%)) or had an overall improvement (13.5% (10.6% to 17.2%)) over time. Yet, 5.2% (3.5% to 7.7%) had a worsening in health status and 4.4% (2.9% to 6.7%) had alternating periods of recovery and health impairment. The point prevalence and severity of covid-19 related symptoms also decreased over time, with 18.1% (14.8% to 21.9%) reporting symptoms at 24 months. 8.9% (6.5% to 11.2%) of participants reported symptoms at all four follow-up time points, while in 12.5% (9.8% to 15.9%) symptoms were alternatingly absent and present. Symptom prevalence was higher among individuals who were infected compared with those who were not at six months (adjusted risk difference 17.0% (11.5% to 22.4%)). Excess risk (adjusted risk difference) for individual symptoms among those infected ranged from 2% to 10%, with the highest excess risks observed for altered taste or smell (9.8% (7.7% to 11.8%)), post-exertional malaise (9.4% (6.1% to 12.7%)), fatigue (5.4% (1.2% to 9.5%)), dyspnoea (7.8% (5.2% to 10.4%)), and reduced concentration (8.3% (6.0% to 10.7%)) and memory (5.7% (3.5% to 7.9%)). Conclusions Up to 18% of individuals who were not vaccinated before infection had post-covid-19 condition up to two years after infection, with evidence of excess symptom risk compared with controls. Effective interventions are needed to reduce the burden of post-covid-19 condition. Use of multiple outcome measures and consideration of the expected rates of recovery and heterogeneity in symptom trajectories are important in the design and interpretation of clinical trials. Study registration Current Controlled Trials [ISRCTN14990068][1] Current Controlled Trials [ISRCTN18181860][2] We are open to sharing de-identified individual participant data that underlie the results reported in this article. Requests can be made to the corresponding author at [email protected]. Data requestors will need to sign a data access agreement. [1]: /external-ref?link_type=ISRCTN&access_num=ISRCTN14990068 [2]: /external-ref?link_type=ISRCTN&access_num=ISRCTN18181860

The BMJ
Madhouse Muse 😷🦋Apr 28, 2023

This professor is a global coronavirus expert. Now he has long COVID.

#LongCovid #SarsCov2 #Covid #COVID19 #PostCovidSequelae

https://www.afr.com/life-and-luxury/health-and-wellness/this-professor-is-a-global-coronavirus-expert-now-he-has-long-covid-20230427-p5d3t7

Long COVID: This professor is a global coronavirus expert. And he has long COVID

Jeremy Nicholson is a world-leader in understanding how disease interacts with people’s genetic make-up. But when he got long COVID, he had a whole new level of insight.

Australian Financial Review
LydiaLuMar 27, 2023

My colleague with well managed type 1 diabetes was running half marathons when we met 2 years ago. After her 2nd Covid infection she developed Rheumatoid Arthritis.

After her recent 3rd Covid infection she can't run at all she tells me yesterday.

Covid is killing and disabling people fast and slow. It's a killer, one way or another. The science and evidence confirms this.

Stay safe friends.

#Covid
#LongCovid
#PostCovidSequelae

LydiaLuJan 26, 2023

Triaging emergency patient's is a new world - marked among young patient's with no history - except Covid in the previous 6 months.

I've been triaging emergency patient's for over 15 years and it's horrific and sad.

Once you see it, you can't unsee it.

The strange rashes, the collapses, palpitations and strange pain. Neck pain, spinal pain, head pain, joint pain. The ongoing, intermittant high fevers. The mottled hands and feet. The infection on infection. The waking in the night unable to breathe. The tachycardia, the elephant on their chest. The relentless cough. The sheer number presenting with diarrhea, WTF.

Young people are not ok.

#LongCovid
#PostCovidSequelae