Gum disease bacterium linked to breast cancer growth and spread
A common oral bacterium tied to gum disease may help spark and fuel breast cancer, according to new research. Scientists discovered it can travel through the bloodstream to breast tissue, where it causes DNA damage and speeds tumor growth and spread. It also appears to make cancer cells more aggressive and resistant to therapy. The effect is even stronger in people with BRCA1 mutations, raising new questions about the role of oral health in cancer risk.
#mwgic #2026 #Dentistry #Periodontitis
New Toothpaste Stops Gum Disease Without Harming Healthy Bacteria https://share.google/PI6I9FRrQH8Nl7xzl
New Toothpaste Stops Gum Disease Without Harming Healthy Bacteria
Researchers have developed a targeted approach to combat periodontitis without disrupting the natural balance of the oral microbiome. The innovation could reshape how gum disease is treated while preserving beneficial bacteria.
Single-cell profiling of the subgingival bacteria reveals transcriptional heterogeneity and niche-specific programs.
Single‑cell RNA atlas reveals functional shifts in subgingival bacteria driving #periodontitis.
https://www.sciencedirect.com/science/article/abs/pii/S1931312826000429 #OpenAccess #OralHealth #microbiota #microbiology
Review of NHANES dietary data for over 1,200 adults aged 65-79 found an association between low lycopene intake and the risk of periodontal disease. Differences were observed by race and sex.
Summary: https://www.sciencedaily.com/releases/2026/02/260208233841.htm
Original paper: https://www.sciencedirect.com/science/article/pii/S1279770725002842
#Science #Health #DentalHealth #Periodontitis #Diet #Lycopene #Tomatoes
This common tomato nutrient may help prevent severe gum disease
A large U.S. study suggests that not getting enough lycopene—the antioxidant that gives tomatoes their red color—may seriously raise the risk of severe gum disease in older adults. Researchers found that seniors with adequate lycopene intake had about one-third the risk of severe periodontitis compared with those who fell short.
A study in Nature shows that M101—an oxygen carrier from the marine worm *Arenicola marina*—significantly reduces inflammation and tissue destruction caused by *P. gingivalis*. A promising step for periodontal therapy! 🧫🌊🦷
Read more: https://www.nature.com/articles/s41598-020-71593-8
#Periodontitis #Inflammation #BiomedicalResearch #ScienceNews
A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction - Scientific Reports
The control of inflammation and infection is crucial for periodontal wound healing and regeneration. M101, an oxygen carrier derived from Arenicola marina, was tested for its anti-inflammatory and anti-infectious potential based on its anti-oxidative and tissue oxygenation properties. In vitro, no cytotoxicity was observed in oral epithelial cells (EC) treated with M101. M101 (1 g/L) reduced significantly the gene expression of pro-inflammatory markers such as TNF-α, NF-κΒ and RANKL in P. gingivalis-LPS stimulated and P. gingivalis-infected EC. The proteome array revealed significant down-regulation of pro-inflammatory cytokines (IL-1β and IL-8) and chemokine ligands (RANTES and IP-10), and upregulation of pro-healing mediators (PDGF-BB, TGF-β1, IL-10, IL-2, IL-4, IL-11 and IL-15) and, extracellular and immune modulators (TIMP-2, M-CSF and ICAM-1). M101 significantly increased the gene expression of Resolvin-E1 receptor. Furthermore, M101 treatment reduced P. gingivalis biofilm growth over glass surface, observed with live/dead analysis and by decreased P. gingivalis 16 s rRNA expression (51.7%) (p < 0.05). In mice, M101 reduced the clinical abscess size (50.2%) in P. gingivalis-induced calvarial lesion concomitant with a decreased inflammatory score evaluated through histomorphometric analysis, thus, improving soft tissue and bone healing response. Therefore, M101 may be a novel therapeutic agent that could be beneficial in the management of P. gingivalis associated diseases.
Target-seeking toothpaste goes after bacteria that cause gum disease
There could be new hope in the fight against gum disease. Scientists have developed a toothpaste that targets only the bacteria that cause periodontitis, leaving the rest of the oral microbiome healthy and intact.
Is Your Oral Bacteria Influencing Multiple Sclerosis? - Neuroscience News
Neuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
Men have higher concentrations of interleukin-1 beta in the gingival crevices between tooth and gum than do women, potentially explaining why inflammation leads to higher levels of periodontitis in men.
Summary: https://medicalxpress.com/news/2025-11-inflammasome-male-specific-bone-loss.html
Original paper: https://www.pnas.org/doi/10.1073/pnas.2507092122
#Science #Health #DentalHealth #Periodontitis #Inflammation
Inflammasome found to drive male-specific bone loss in gum disease
A study out of the University of North Carolina at Chapel Hill has unveiled new insights into the inflammatory processes behind periodontitis, a common and debilitating gum disease. Research conducted by UNC Adams School of Dentistry's Julie Marchesan, DDS, Ph.D., and UNC School of Medicine's Jenny Y. Ting, Ph.D., found that a part of the immune system called the inflammasome plays a key role in disease development, and that blocking this system prevents bone resorption only in males.
Dan Stafford
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