Mastodawn

PLOS Biology Oct 1, 2024

#Tuberculosis bacteria release tuberculosinyladenosine to help them survive in human #macrophages. This study identifies >100 such #terpene #nucleoside metabolites, revealing how #TB's ancestors acquired the genes to make these lipids #PLOSBiology https://plos.io/4gIfmol

Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides

Mycobacterium tuberculosis releases 1-tuberculosinyladenosine to block lysosomal function and promote survival in human macrophages. This study identifies over 100 such terpene nucleoside metabolites, revealing how ancestral M. tuberculosis complex bacteria acquired the genes needed to make these unique bioactive lipids.

The EMBO Journal Jul 14, 2023

How do mitochondria obtain the #ribonucleotides they need for organellar transcription?
Thomas MacVicar, Thomas Langer and colleagues show key fueling role of #mitochondrial #nucleoside diphosphate kinase #NME6 that phosphorylates #pyrimidine nucleosides
https://www.embopress.org/doi/full/10.15252/embj.2022113256

Marco Radi Jul 5, 2023

#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200

CellBioNews Jun 21, 2023

#Nucleoside analogs for messenger #RNA metabolic labeling and #sequencing.

https://phys.org/news/2023-06-nucleoside-analogs-messenger-rna-metabolic.html

Nucleoside analogs for messenger RNA metabolic labeling and sequencing

High-throughput RNA-sequencing (RNA-seq) is widely used to profile global cellular gene expression and gain insights into cellular biological processes; however, effectively tracking dynamic changes in cellular mRNA expression remains a challenge. Being able to do so can help researchers to investigate transcripts over a time frame.

Phys.org

Giuseppe Michieli May 10, 2023

Development of a #nucleoside-modified #mRNA #vaccine against clade 2.3.4.4b #H5 highly pathogenic #avian #influenza virus, https://doi.org/10.1101/2023.04.30.538854

Chemistry Research Dec 14, 2022

Carbasugar #nucleoside analogues often lack biological activity, which is attributed to an unfavorable conformation. Locked nucleoside analogues, however, can mantain the ribose-like conformation. Another synthetic access is published in #OrgLett by Lak Shin Joeng and colleagues from Seoul National University (S. #Korea)

They were able to report the synthesis of the conformationally locked cytidine nucleoside analogue in 19 steps.

#chemistry #MedChem @chemistry
https://pubs.acs.org/doi/10.1021/acs.orglett.2c03853

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Joseph P.Dec 4, 2022

It is expected to be a promising agent in the treatment of various ailments and diseases.

Adenosine can be metabolized both externally and internally. Externally, an enzyme called adenosine deaminase is responsible for transforming adenosine into inosine. Additionally, a protein called equilibrative #nucleoside #transporters (ENTs) helps to bring the #extracellular activity of adenosine to an end.