Systematically towards new therapies

In our "EXplained" video series, we introduce the seven Clusters of Excellence at our university. One of these is the Munich Cluster for Systems Neurology – SyNergy, represented at TUM by Prof. Thomas Misgeld, Director of the Institute of Neuronal Cell Biology.

Ablation of HDAC8 accelerates the regeneration of neurons and the recovery of the sensory function | Press and Public Relations

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Jellyfish show how you don’t need a brain to learn, say researchers

Adjustment of behaviour shown in study suggests learning is integral function of neurons

Jellyfish shown to learn from past experience for the first time

Jellyfish are more advanced than once thought. A new study from the University of Copenhagen has demonstrated that Caribbean box jellyfish can learn at a much more complex level than ever imagined—despite only having one thousand nerve cells and no centralized brain. The finding changes our fundamental understanding of the brain and could enlighten us about our own mysterious brains.

Mapping the structure of Huntington’s brain clumps

People with Huntington’s disease lose control of their bodies and minds. The symptoms are caused by protein clumps in the nerve cells. Supported by a Marie Skłodowska-Curie Individual Fellowship, Andrea Quezada aims to create atomic models of these fibrils at the Max Delbrück Center.

We've finally identified the nerve cells in the clitoris and penis that respond to vibration

A new study in mice shows that Krause corpuscles are specialized to respond to vibration and light touch, and are key to normal sexual behavior.

Poorly insulated nerve cells shown to promote Alzheimer's disease in old age

Alzheimer's disease, an irreversible form of dementia, is considered the world's most common neurodegenerative disease. The prime risk factor for Alzheimer's is age, although it remains unclear why. It is known that the insulating layer around nerve cells in the brain, named myelin, degenerates with age. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen have now shown that such defective myelin actively promotes disease-related changes in Alzheimer's. Slowing down age-related myelin damage could open up new ways to prevent the disease or delay its progression in the future.