Scholpp_Lab
James Briscoe"Is there a recent review of the #morphogen control of tissue patterning that I can read on my summer hols?" I hear you ask
Why, yes, there is. Here's @AKicheva & my summary of the current state of the field & open questions
@CellySally I agree with everything you said. However, could a cell react without the external trigger of a chemical signal? And how could this cell react if it would not express the appropriate receptor for signal integration? Everything else will follow. #morphogen #morphogenesis #DevBio
Alexey VeraksaA thoughtful review on how Dpp/BMP functions as a #morphogen in the #Drosophila wing to control growth and patterning. There is still much to learn!
#DevBio
https://doi.org/10.1002/bies.202200218
#DevBio
https://doi.org/10.1002/bies.202200218
Dagmar IberOur paper builds on previous work from our group that
- introduced the 1D morphogen gradient model:
https://twitter.com/DagmarIber/status/1499631526056796162
- revealed the impact of cell size on patterning precision:
https://twitter.com/DagmarIber/status/1489479705292156933
- explored the effect of non-linear decay:
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RT @DagmarIber
Does self-enhanced #morphogen #degradation improve #patterning #precision in #tissue #development? …
https://twitter.com/DagmarIber/status/1589511772285054976
The #positional #error of a #morphogen #gradient significantly decreases as the patterned #tissue widens. It can drop from above one #cell diameter to below half a cell diameter, before saturating at a #tissue width beyond about 10 cells.
How to achieve high #patterning #precision in #development?
#Morphogen gradients are more precise in #2D than in 1D, in particular when #cells are #narrow.
Check out our latest #preprint on @biorxivpreprint: https://doi.org/10.1101/2023.03.13.532369
PLOS BiologyStudy shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO
The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO
The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO
The epithelial polarity genes frazzled and GUK-holder adjust morphogen gradients to coordinate changes in cell position with cell fate specification
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
J.P. Vincent LabHi everyone!
The Vincent lab twitter account completes its migration to Mastodon.
Follow us for cool #DevBio science, mostly working with #Drosophila. We are generally interested in the signalling activities that control patterning, growth and apoptosis in epithelia. Our #morphogen of choice is #Wnt.
Here you may also find the occasional rant from JP once he gets used to the new format. Until then, this account is mostly managed by postdoc Ines.